Synthesis of Alkyne-Terminated PCDA Linker for Applying Click Chemistry on PDA Layers

This review presents well-defined copper and nickel complexes that have been used in the formation of CÀ S bonds. The use of Cu or Ni catalysts represent an advantage in comparison with those based on precious metals such as Pd, by being two of the most abundant metals in the earth's crust and thus cheaper. As can be expected the catalytic activity of the different Cu and Ni complexes is strongly dependent on the nature of the ligands used. Thus, multidentate and strong electron-donating ligands are of common use to design highly active species since such ligands are capable to stabilize species in high oxidation states which are key intermediates in the reaction mechanisms of these processes. This being particular true in the case of copper, where Cu(III) produces unstable and reactive species that require an "extra stabilization" during the reaction mechanism. Hence, the reaction mechanisms using copper and nickel complexes as catalysts are also discussed in this paper, including the role of the different ligands during the catalytic processes. Although there is an increasing number of reports on CÀ S cross coupling reactions, due to the relevance of this transformation, they are often difficult to reproduce and not of general use since the actual catalytic species are not identified. Thus, we hope that this report will help to promote the search and synthesis of new ligands for the design of more active welldefined complexes that can be used as catalysts in a more rational manner in the formation of valuable CÀ S bondcontaining species.

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C−S Cross‐Coupling Reactions Catalyzed by Well‐Defined Copper and Nickel Complexes

Rufino‐Felipe

Valdés

Morales‐Morales

2022

Eur J Org Chem

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Fluorescence-Based Multiplex Protein Detection Using Optically Encoded Microbeads

et al. 2012

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Potential utilization of proteins for early detection and diagnosis of various diseases has drawn considerable interest in the development of protein-based multiplex detection techniques. Among the various techniques for high-throughput protein screening, optically-encoded beads combined with fluorescence-based target monitoring have great advantages over the planar array-based multiplexing assays. This review discusses recent developments of analytical methods of screening protein molecules on microbead-based platforms. These include various strategies such as barcoded microbeads, molecular beacon-based techniques, and surface-enhanced Raman scattering-based techniques. Their applications for label-free protein detection are also addressed. Especially, the optically-encoded beads such as multilayer fluorescence beads and SERS-encoded beads are successful for generating a large number of coding.

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Synthesis of Alkyne-Terminated PCDA Linker for Applying Click Chemistry on PDA Layers

Cited by 2 publications

References 12 publications

C−S Cross‐Coupling Reactions Catalyzed by Well‐Defined Copper and Nickel Complexes

C−S Cross‐Coupling Reactions Catalyzed by Well‐Defined Copper and Nickel Complexes

Fluorescence-Based Multiplex Protein Detection Using Optically Encoded Microbeads

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