Synthesis of aminals from 8-aminoquinoline

Development of the catalytic synthesis of compounds of the quinoline series (the N. S. Kozlov reaction) (Review)*

“…Triple-component condensation is particularly effective in cases where it is difficult to isolate the azomethines in the crystalline state [61] or aminals are formed instead of azomethines [67,68]. At the same time the formation of azomethines as intermediates and their subsequent acid-catalyzed reaction with the methyl ketones is the most likely path for the synthesis of the above-mentioned azaphenanthrene derivatives.…”