Synthesis of aminofuropyridines via the reaction of aminosilanes with pyridoxal

Reaction of pyridoxal imine with phosphonic acid derivatives

“…The action of pyridoxal as cofactor in most enzymatic reactions involves initial formation of Schiff bases with substrates. Up to now, a large number of functionalized derivatives of pyridoxal have been synthesized, including Schiff bases possessing biological activity [1][2][3][4][5][6][7]. Reactions of PH-containing compounds with Schiff bases derived from pyridoxal have not been reported.…”