Synthesis of ammonium substituted β-cyclodextrins for enantioseparation of anionic analytes

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

“…Researchers at Nanyang Technological University have contributed several papers to the field of cationic CD synthesis and application [136][137][138][139][140][141][142][143]. A very brief study described Mono-6^-propylammonium-6^-deoxy-CD (PrAM-b-CD)…”

“…Novel single isomer cationic CD [143] QA-b-CD Two dianionic enantiomers Chiral recognition study utilizing NMR the synthesis of three different cationic b-CDs: imidazolium, pyridinium, and quaternary ammonium substituted b-CDs [136]. BuAM-b-CD (mono-6^-butylammonium-6^-deoxy-b-CD tosylate), a single isomer CD, was created and shown to be an effective chiral selector [137] for three types of chiral analytes: hydroxy acids, carboxylic acids, and ampholytic acids with the latter two classes, in general, shown to weakly bind with the positive CD.…”

Functionalized assembly of solid membranes for chiral separation using polyelectrolytes and chiral ionic liquid

“…[27][28][29] The synthetic route of mono-6-OTs-b-CD is shown in Figure 1. 75.0 g (0.066 mol) of b-CD was dissolved slowly in 625 mL deionized water below 20 C to generate a turbid white suspension.…”

Polymerization of Cyclodextrin-Ionic Liquid Complexes for the Removal of Organic and Inorganic Contaminants from Water

“…NaOH), the proton at C-6 is removed to make O -which is a nucleophile that can be easily substituted. Thus when a CD is reacted with a tosyl group in a basic medium, a monofunctionalised CD derivative (CDOTs) is afforded (Byun et al, 1998;Muderawan et al, 2005;Zhong et al, 1998). The CDOTs is an important precursor for all C-6 CD derivatives because the tosylate is a good leaving group and can be easily replaced by other nucleophiles (e. g. halogens, azides and acetates).…”