Synthesis of amphiphilic poly(N‐vinylcaprolactam) using ATRP protocol and antibacterial study of its silver nanocomposite

Abstract

Atom transfer radical polymerization (ATRP) of N‐vinylcaprolactam (NVCL) was studied by uisng ethyl‐2‐bromoisobutyrate (EIB) as initiator in 1,4‐dioxane. It led to controlled radical polymerization of NVCL, with the molecular weight increased along with the conversion of monomer and a relatively narrow molecular weight distribution could be obtained, as determined by gel permeation chromatography. 1H NMR showed that the major population of poly(N‐vinylcaprolactam) (PVCL) retained the chain‐end functional group. The living nature of the ATRP for NVCL was confirmed by the experiments of PVCL chain extension. PVCL was further investigated for its ability to form micelles in aqueous media. Self‐assembling of the amphiphilic PVCL leads to the formation of their micellar aggregates in aqueous media which was confirmed by transmission electron microscope. The critical micelle concentration value was calculated from the photophysical changes of Pyrene‐1‐Carboxaldehyde by UV absorption studies and was found to be 0.0320 mg/mL. The polymer nanocomposite was synthesized and examined in view of antibacterial effect against Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Proteus mirabilis, and Klebsiella pneumonae. It was found that polymer nanocomposite possess strong antibacterial activity against Enterococcus faecalis with minimum inhibitory concentration value of 32 μg/mL. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

Mesoporous silica particles grafted with poly(ethyleneoxide‐block‐N‐vinylcaprolactam)

“…The supernatant was washed and centrifuged using consecutively toluene (33), methanol (32), toluene (31), and dichloromethane (31). Washing with methanol removes also most of the surfactant from the pores.…”

“…In this case, the polymer molecular masses were rather low, below 8000 g=mol. 33 Recently, Jiang et al 34 prepared poly(tertbutyl acrylate) grafted with PVCL. These polymers were synthesized with ATRP polymerization and the control over molecular weight was good.…”

Polyisobutylene-b -Poly(N,N -diethylacrylamide) well-defined amphiphilic diblock copolymer: Synthesis and thermo-responsive phase behavior

“…LCSTs of PIB-b-PDEAAm 2 diblock copolymers were in the range of 29.0 to 31.8 o C and they rose with the increasing of the number of DEAAm repeated unit, which was similar to previous reports. [40][41][42] Further insight into the thermo-responsive behavior of PIBb-PDEAAm 2 diblock copolymer was investigated by DLS. Figure 8 show the dependence of hydrodynamic diameter (D h ) of PIB-b-PDEAAm 2 diblock copolymer on the temperature.…”

Synthesis of Well-Defined Vinyl End-Functional Polystyrene Using Multifunctional Initiator by Atom Transfer Radical Polymerization

“…Well-defined end functional polymers are useful as building blocks for design and synthesis of various complex macromolecular architectures such as block (Guillerm et al, 2012;Wang et al, 2013;Glaied et al, 2014), graft (Zhang et al, 2012;Lav et al, 2013), star (Cai et al, 2012;Ratkanthwar et al, 2013) copolymers etc. which find applications in biomedical (Bauer et al, 2013), tissue engineering (Martina and Hutmacher, 2007), materials (Singh et al, 2012) and surface sciences (Lee et al, 2007). Although various end-functional polymers are reported so far, the synthesis of amide group containing reactive end-functional polymers still have an interest due to it's protein coupling ability to polymer and biomedical applications (Boyer et al, 2011).…”