Synthesis of an MOF-based Hg<sup>2+</sup>-fluorescent probe <i>via</i> stepwise post-synthetic modification in a single-crystal-to-single-crystal fashion and its application in bioimaging

Li, Wenyan; Song, Yang; Li, Yanan; Li, Qian-Ying; Guan, Qun; Dong, Yu‐Bin

doi:10.1039/c9dt02866h

Cited by 29 publications

(16 citation statements)

References 30 publications

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“…This is possibly why the synthesis of single crystals of UiO-68 by using H2TPDC ([1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid) linkers remains still elusive, and all crystals available rely on amine, alcohol or alkyl derivatives with subsequent changes to the porosity or physical properties of the pristine material. 5,6,7 The availability of single crystals is particularly important in understanding the dynamic exchange reactions often used to produce multivariate frameworks by post-synthetic (PSE) 8 or solvent-assisted linker exchange (SALE) 9 . The porosity of the framework and the concentration of the exchanged linker control the diffusion of the last.…”

Section: Introductionmentioning

confidence: 99%

“…This problem is even more severe for the mesoporous derivatives, which require the use of elongated linkers with very poor solubility in the organic solvents used in the synthesis. This is possibly why the synthesis of single crystals of UiO-68 using H 2 TPDC ([1,1′:4′,1″-terphenyl]-4,4″-dicarboxylic acid) linkers still remains elusive, and all crystals available rely on amine, alcohol, or alkyl derivatives with subsequent changes to the porosity or physical properties of the pristine material. − …”

Section: Introductionmentioning

confidence: 99%

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Effect of Linker Distribution in the Photocatalytic Activity of Multivariate Mesoporous Crystals

et al. 2021

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The use of Metal-Organic Frameworks as crystalline matrices for the synthesis of multiple component or multivariate solids by the combination of different linkers into a single material has emerged as a versatile route to tailor the properties of single component phases or even access new functions. This approach is particularly relevant for Zr6-MOFs due to the synthetic flexibility of this inorganic node. However, the majority of materials is isolated as polycrystalline solids, which are not ideal to decipher the spatial arrangement of parent and exchanged linkers for the formation of homogeneous structures or heterogeneous domains across the solid. Here we use High-Throughput methodologies to optimize the synthesis of single crystals of UiO-68 and UiO-68-TZDC, a photoactive analogue based on a tetrazine dicarboxylic derivative. The analysis of the single linker phases reveals the necessity of combining both linkers to produce multivariate frameworks that combine efficient light sensitization, chemical stability and porosity, all relevant to photocatalysis. We use solvent assisted linker exchange reactions to produce a family of UiO-68-TZDC% binary frameworks, which respect the integrity and morphology of the original crystals. Our results suggest that the concentration of TZDC in solution controls the distribution of this linker in the sibling crystals for a random mixture or the formation of core-shell domains. We also demonstrate how the possibility of generating an asymmetric distribution of both linkers has a negligible effect on the electronic structure and optical bandgap of the solids but controls their performance for drastic changes in the photocatalytic activity towards proton or methyl viologen reduction.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Linker Distribution in the Photocatalytic Activity of Multivariate Mesoporous Crystals

et al. 2021

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“…have successfully synthesized three new UiO‐MOFs via post‐synthetic modification (PSM)‐based single‐crystal‐to‐single‐crystal method. [ 111 ] Notably, UiO‐68‐R6G among them used for Hg 2+ sensing exhibited strong fluorescence for bioimaging both in vitro and in vivo .…”

Section: Mofs For Bioimaging In Vivomentioning

confidence: 99%

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†

et al. 2021

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Metal‐organic frameworks (MOFs) as a class of porous functional materials have attracted more and more attention for biomedical applications. To date, MOFs have been developed for bioimaging based on a series of advantages such as the large surface areas, high porosity, fluorescence functionalities and good biocompatibility. It is worth noting that organic or inorganic fluorescent materials such as fluorescent dyes, quantum dots, metal nanoclusters and nanosheets can combine MOFs or be encapsulated in MOFs to form fluorescent nanocomposites for excellent imaging function. Importantly, excellent imaging capabilities are of great significance in living cells and in vivo for detection, diagnosis and cancer therapy. In this review, we focus on the recent research of the bioimaging in living cells and in vivo based on various MOF‐based nanocomposites and their potential biological clinical applications.

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“…Crystal engineering is one of the amazing research fields in chemistry which combines chemistry and art to rationally design and create new structural architectures with desired properties and applications. 13 In this regard, an explosion of interest in the design and synthesis of coordination polymers (CPs) and its unique subclass, that is, metal–organic frameworks (MOFs), has occurred over the past few decades due to their outstanding properties and a myriad of possible applications, which include traditional uses of microporous materials, such as gas storage, separation, and catalysis, 14 − 16 as well as new realms in biomedicine, 17 , 18 electronic devices, and information storage. 19 , 20 MOFs are a fascinating class of porous crystalline substances that are composed of multidentate organic linkers and inorganic metal nodes that form exciting three-dimensional frameworks.…”

Section: Introductionmentioning

confidence: 99%

Design of a Sensitive Fluorescent Zn-Based Metal–Organic Framework Sensor for Cimetidine Monitoring in Biological and Pharmaceutical Samples

et al. 2022

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A new highly fluorescent zinc–organic framework [Zn 2 (btca)(DMSO) 2 ] n ( Zn-MOF ) was prepared via in situ ligand formation by the solvothermal reaction of Zn(NO 3 ) 2 ·6H 2 O and pyromellitic dianhydride (PMDA) in DMSO solvent. During the solvothermal reaction, PMDA was gradually hydrolyzed to a pyromellitic acid, 1,2,4,5-benzene tetracarboxylic acid (H 4 btca), to provide a tetracarboxylic acid as a linker in the reaction medium. Single-crystal X-ray diffraction analysis exhibits a 3D porous structure with open tetragonal channels running along the crystallographic c -axis. The Zn-MOF was explored as an on-mode fluorescent sensor for tracing cimetidine in biological fluids and pharmaceutical samples in the presence of interfering species. The results show a quick response in a short time range. The characteristics of this sensor were investigated by field-emission scanning electron microscopy, dynamic light scattering, energy-dispersive X-ray analysis, powder X-ray diffraction, Fourier transform infrared and UV–vis spectroscopy as well as thermogravimetric, and elemental analyses.

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Synthesis of an MOF-based Hg²⁺-fluorescent probe via stepwise post-synthetic modification in a single-crystal-to-single-crystal fashion and its application in bioimaging

Abstract: A new MOF-based Hg2+ fluorescent sensor, UiO-68-R6G, was prepared via successive single-crystal-to-single-crystal post-synthetic modification; this sensor could detect Hg2+ both in vitro and in vivo with high sensitivity and selectivity.

Cited by 29 publications

References 30 publications

Effect of Linker Distribution in the Photocatalytic Activity of Multivariate Mesoporous Crystals

Effect of Linker Distribution in the Photocatalytic Activity of Multivariate Mesoporous Crystals

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†

Design of a Sensitive Fluorescent Zn-Based Metal–Organic Framework Sensor for Cimetidine Monitoring in Biological and Pharmaceutical Samples

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Synthesis of an MOF-based Hg2+-fluorescent probe via stepwise post-synthetic modification in a single-crystal-to-single-crystal fashion and its application in bioimaging

Abstract: A new MOF-based Hg2+ fluorescent sensor, UiO-68-R6G, was prepared via successive single-crystal-to-single-crystal post-synthetic modification; this sensor could detect Hg2+ both in vitro and in vivo with high sensitivity and selectivity.

Cited by 29 publications

References 30 publications

Effect of Linker Distribution in the Photocatalytic Activity of Multivariate Mesoporous Crystals

Effect of Linker Distribution in the Photocatalytic Activity of Multivariate Mesoporous Crystals

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo†

Design of a Sensitive Fluorescent Zn-Based Metal–Organic Framework Sensor for Cimetidine Monitoring in Biological and Pharmaceutical Samples

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Product

Resources

About

Synthesis of an MOF-based Hg²⁺-fluorescent probe via stepwise post-synthetic modification in a single-crystal-to-single-crystal fashion and its application in bioimaging

Metal‐Organic Frameworks‐Based Fluorescent Nanocomposites for Bioimaging in Living Cells and in vivo^†