Synthesis of aryl ?-heterylethyl ketones

Reactions of β-aroylacrylic acids with N-nucleophiles

“…It is known 1-8 that in reactions with water and NH, SH, CH, and PH acids, a nucleophile attacks the C α atom to form α substituted β aroylpropionic ac ids. Quantum chemical 9 and experimental data are in agreement. It should be noted that β aroylacrylic acids form salts with heterocyclic amines, thiourea, and thio semicarbazide.…”