Synthesis of arylthioacetamidoximes as potential antidepressants

Abstract

Reactions of thiophenol and 16 of its derivatives with chloroacetonitrile afforded arylthioacetonitriles IVb-XXb which were treated with hydroxylamine and gave arylthioacetamidoximes IVa-XXa. Compounds VIIa-IXa, XIIa, XVIa and XVIIIa exhibited antireserpine activity in the test of ptosis in mice and compounds IXa and XVIIa in the test of reserpine hypothermia in mice.

Magnesium methoxide complexation in the control of chemical reactions

“…-Methyl 3-amin0-2-cyano-4-phenyIsulfinylbut-Zenoa te38 Phenyl cyanomethyl sulfoxide 37 (0.495 g, 3 mmol) was added to a stirred solution of magnesium methoxide [from magnesium (0.072 g, 3 mmol) and anhydrous methanol (12 cm-')]. Methyl cyanoacetate (0.297 g, 3 mmol) was then added and the solution was refluxed for 20 h. The solvent was evaporated and the residue was washed with diethyl ether.…”