Synthesis of Arylthiopyrimidines by Copper‐catalyzed Aerobic Oxidative C–S Cross‐coupling

Lee, Ok Suk; Kim, Hyeji; Lee, Hee-Seung; Shin, Hyunik; Sohn, Jae Hak

doi:10.1002/bkcs.10641

Cited by 35 publications

(47 citation statements)

References 35 publications

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“…The LODs for d ‐fructose or d ‐galactose were not determined. Probe uncapping was explained by the displacement of bulky cyclodextrins by the competitive interaction of monosaccharides with boronic acid moieties . It is also worth mentioning that, despite not having been designed specifically for sensing purposes, other authors have developed selective glucose‐responsive systems, and have used them for the glucose‐induced release of insulin, which was related directly with the amount of glucose present in media …”

Section: Sensing Of Small Neutral Moleculesmentioning

confidence: 99%

Gated Silica Mesoporous Materials in Sensing Applications

et al. 2015

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Silica mesoporous supports (SMSs) have a large specific surface area and volume and are particularly exciting vehicles for delivery applications. Such container-like structures can be loaded with numerous different chemical substances, such as drugs and reporters. Gated systems also contain addressable functions at openings of voids, and cargo delivery can be controlled on-command using chemical, biochemical or physical stimuli. Many of these gated SMSs have been applied for drug delivery. However, fewer examples of their use in sensing protocols have been reported. The approach of applying SMSs in sensing uses another concept—that of loading pores with a reporter and designing a capping mechanism that is selectively opened in the presence of a target analyte, which results in the delivery of the reporter. According to this concept, we provide herein a complete compilation of published examples of probes based on the use of capped SMSs for sensing. Examples for the detection of anions, cations, small molecules and biomolecules are provided. The diverse range of gated silica mesoporous materials presented here highlights their usefulness in recognition protocols.

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Section: Sensing Of Small Neutral Moleculesmentioning

confidence: 99%

Gated Silica Mesoporous Materials in Sensing Applications

et al. 2015

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“…We previously reported the substituent chemical shifts of 2-aryl derivatives of benzimidazole, benzimidazolium ion, and benzimidazolone. 10 However, the carbon atoms of interest were directly bonded to the substituted benzene ring compared to the present systems in which the carbon atoms are separated by an ester group.…”

Section: Articlementioning

confidence: 85%

How Much Does the Hybridization of a Carbon Atom Affect the Transmission of the Substituent Effect on the Chemical Shift?

Jeong

Lee

2015

Bulletin Korean Chem Soc

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1H and 13 C NMR spectra of aryl esters of propionic acid, acrylic acid, and propiolic acid were systematically examined to find out the substituent effect on the chemical shift. The values of the chemical shift of the carbonyl carbon showed an inverse correlation with the Hammett σ values, and the magnitude of the slope was the largest with the propiolates. The α carbons of acrylates and propiolates also showed an inverse correlation with much smaller values of the slopes than those of the carbonyl carbons; but those of the propionates showed absolutely no correlation. However, the β carbons of acrylates and propiolates showed normal correlation with larger values of the slopes. The signs and the magnitudes of the slopes may be understood by the transmission of the substituent electronic effect through bonds as well as through space. The propiolyloxy group also showed a significantly large effect on the 13 C chemical shift values of the benzene ring.

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“…Interestingly, all of the target compounds, except nonacetal derivatives ( 4 ) and synthetic intermediates such as 10‐substituted sulfidylyl ( 6 ) and sulfonyldihydroartemisinin ( 7 ), inhibited angiogenesis, which is a key step in the growth, invasion, and metastasis of tumors, and can be an important therapeutic strategy for cancer and related diseases . Recently, we also reported the synthesis of 10‐substituted triazolyl artemisinins ( 8 ) and their strong cytotoxicity against various cancer cells . Over the course of about 15 years of our novel drug discovery program, we have prepared four types of artemisinin mimic libraries derived from artemisinin as shown in Figure , and using these libraries, we have identified a potential osteoporosis drug candidate.…”

Section: Synthesis Of 10‐exomethylene Artemisinin (9) Using Tebbe Andmentioning

confidence: 99%

Efficient Synthesis and Stimulatory Effect of C‐10 Exo‐methylene Artemisinin on MC3T3‐E1 Preosteoblast Differentiation to Osteoblasts

Namkung

Lee

2016

Bulletin Korean Chem Soc

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Synthesis of Arylthiopyrimidines by Copper‐catalyzed Aerobic Oxidative C–S Cross‐coupling

Cited by 35 publications

References 35 publications

Gated Silica Mesoporous Materials in Sensing Applications

Gated Silica Mesoporous Materials in Sensing Applications

How Much Does the Hybridization of a Carbon Atom Affect the Transmission of the Substituent Effect on the Chemical Shift?

Efficient Synthesis and Stimulatory Effect of C‐10 Exo‐methylene Artemisinin on MC3T3‐E1 Preosteoblast Differentiation to Osteoblasts

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