Synthesis of Au13(glutathionato)8@β-cyclodextrin nanoclusters and their use as a fluorescent probe for silver ions

Wang, Meilan; Wu, Huan; Chi, Yuwu

doi:10.1007/s00604-014-1253-2

Cited by 15 publications

(3 citation statements)

References 39 publications

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“…Jin’s group used borohydride to accelerate the formation of GSH coated Au NCs . Considering that external heat can also accelerate the nucleation of the luminescent AuGSH sample, , here we investigated the possible rapid synthesis of AuGSH at lower temperatures. Weak but distinguishable PL emission only emerges for the mixture of HAuCl 4 and GSH (molar ratio of AuCl 4 – :GSH at 1:1) at a temperature higher than 60 °C for 2 h (Figure S1, Supporting Information (SI)).…”

Section: Resultsmentioning

confidence: 99%

Thiols-Induced Rapid Photoluminescent Enhancement of Glutathione-Capped Gold Nanoparticles for Intracellular Thiols Imaging Applications

Jiang

Wang

2015

Anal. Chem.

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The rapid detection and imaging of intracellular thiols is of great importance during the occurrence and development of some chronic diseases. Here we demonstrate the rapid thiols-induced photoluminescence (PL) enhancement of the low luminescent glutathione (GSH) stabilized Au nanoparticles, AuGSH (low). The dynamic PL investigation reveals that the PL enhancement fits a first-order reaction model. The X-ray photoelectron spectroscopic and mass spectroscopic results indicate that AuGSH (low) are mainly comprised of "thiols-insufficient" Au species and the additional thiols can efficiently attach to the "unsaturated" surface of Au nanoparticles, accompanied by significant PL enhancement. The noncytotoxic AuGSH (low) probe can be successfully applied for imaging of intracellular thiols. Generally, this work illustrates the great prospects of facile-prepared AuGSH (low) as a candidate for thiols labeling and imaging.

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Section: Resultsmentioning

confidence: 99%

Thiols-Induced Rapid Photoluminescent Enhancement of Glutathione-Capped Gold Nanoparticles for Intracellular Thiols Imaging Applications

Jiang

Wang

2015

Anal. Chem.

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“…Cyclodextrin (CD)-capped Au–SG NCs have been used to probe Ag(I) in water in the concentration range between 0.5 nM and 0.1 μM, with a detection limit at 0.3 nM. 21 In another report, Mathew et al have presented interaction between an atomically precise 25-atom Au NC anchored to a ligand and β-CD. 22 They have showed that the CD moieties present on the cluster surface provide enhanced stability.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanocluster-Grafted Cyclodextrin Suprastructures: Formation of Nanospheres to Nanocubes with Intriguing Photophysics

2018

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Glutathione (GSH)-coated gold nanoclusters (Au NCs) were synthesized in aqueous acidic medium. On deprotonation of the carboxyl groups of the GSH molecules under alkaline condition, the anionic ends react with the added cationic surfactant molecules to convert the Au NCs hydrophobic, resulting in loss of fluorescence due to apparent insolubility in water. The fluorescence is revived by adding cyclodextrins (CDs) that encapsulate the protruding hydrophobic tails of the surfactant molecules surrounding the GSH-coated Au NCs. While addition of β-CD showed maximum revival of the Au NC fluorescence, that by adding α-CD was lesser. Interestingly, on adding γ-CD, there was no increase in fluorescence of Au NCs at all. The size of CDs varies as γ- > β- > α-. It appears that the cavity size of the CD-hosts controls the fluorescence from the Au NCs abruptly, and the reason behind that was found to be formation of suprastructures, the shapes of which varied from spherical to cubic. The work shows the production of Au NC-grafted CD suprastructures that develop fluorescence on–off composites on the basis of their overall shapes.

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“…β-CD can form an inclusion complex when an organic molecule enters its hydrophobic cavity. Several sensors in which organic molecules are selectively associated with the hydrophobic cavities of cyclodextrins have been developed [11][12][13][14]. Graphene oxide (GO), which is a two-dimensional nanosheet, has effective electron transfer properties that allow it to strongly quench fluorescence, and these properties have been used creatively in the construction of GO-quenched optical sensors for various analytes [15][16][17].…”

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confidence: 99%

Turn-on fluorometric β-carotene assay based on competitive host-guest interaction between rhodamine 6G and β-carotene with a graphene oxide functionalized with a β-cyclodextrin-modified polyethyleneimine

Liu

et al. 2016

Microchim Acta

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The authors describe a "turn-on" fluorometric method for determination of β-carotene. It is based on competitive host-guest interaction between rhodamine 6G (R6G) and β-carotene and graphene oxide nanoparticles that were functionalized with β-cyclodextrin (β-CD)-modified polyethylenimine (β-CD-PEI-GO). On addition of R6G to a solution of β-CD-PEI-GO, its fluorescence is quenched because of the inclusion of R6G into the β-CD moiety. Both Förster resonance energy transfer and electron transfer are likely to occur. On further addition of a sample containing β-carotene, it will replace R6G in the cavity, thereby releasing R6G to the bulk solution. This is due to the stronger affinity of β-carotene for β-CD in the complex, but also because of repulsion between the positively charged β-CD-PEI-GO complex and the positively charged R6G dye. The displacement of R6G by β-carotene leads to fluorescence recovery whose efficiency (expressed as F/F 0 ) is related to the β-carotene concentration in the range from 0.1 to 4.0 μmol⋅L‾ 1 . The detection limit for β-carotene is 5.4 nmol⋅L‾ 1 which is lower than that of any other optical method.

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Synthesis of Au13(glutathionato)8@β-cyclodextrin nanoclusters and their use as a fluorescent probe for silver ions

Cited by 15 publications

References 39 publications

Thiols-Induced Rapid Photoluminescent Enhancement of Glutathione-Capped Gold Nanoparticles for Intracellular Thiols Imaging Applications

Thiols-Induced Rapid Photoluminescent Enhancement of Glutathione-Capped Gold Nanoparticles for Intracellular Thiols Imaging Applications

Gold Nanocluster-Grafted Cyclodextrin Suprastructures: Formation of Nanospheres to Nanocubes with Intriguing Photophysics

Turn-on fluorometric β-carotene assay based on competitive host-guest interaction between rhodamine 6G and β-carotene with a graphene oxide functionalized with a β-cyclodextrin-modified polyethyleneimine

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