Synthesis of B6 vitamin

Abstract

The importance of vitamin B6 has been known since its discovery in the 1940's. Chemical tests, elestrometric titration determinations, and absorption spectrum studies showed that this vitamin exists in three major chemical forms: pyridoxine (an alcohol), pyridoxal (an aldehyde), and pyridoxamine (a primary amine). Vitamin B6 is needed for more than 100 enzymes involved in protein metabolism, and it is assumed that this vitamin is cofactor of metabolic processes more important than any other substance. A deficiency of vitamin B6 in the human diet leads to severe disorders. Vitamin B6 is necessary for the proper function of the immune and nervous system, and helps the body convert protein to energy. This paper describes the history, properties and applications of vitamin B6, elucidation of chemical structure, and different procedures for synthesis of pyridoxine and pyridoxamine

Synthesis, solvatochromism, and biological activity of novel azo dyes bearing 2-pyridone and benzimidazole moieties

“…2 2-Pyridone derivatives possess pharmacological and a wide range of therapeutic activities. 17 They exhibit antimicrobial, 18 antiviral, 19 anti-HIV, 20 anticancer, 21 cardiotonic, 22 and vasorelaxant activities. 23 Pharmaceutically active derivatives obtained by a combination of benzimidazole and antimicrobial active 2-pyridone rings have also been synthesized and their potential biological applications have been observed.…”

Micronutrient Therapy for Violent and Aggressive Male Youth: An Open-Label Trial

“…In the context of violent and aggressive behaviors, vitamin B6 is an understudied micronutrient. Due to the high affinity that HPL has for the aldehyde structure of vitamin B6, further research into the identification of this mechanism and its role in vitamin B6 depletion and behavior is crucially needed (Vucijak et al 2009).…”