Synthesis of benzimidazoles/benzothiazoles by using recyclable, magnetically separable nano-Fe2O3 in aqueous medium

Dileep, Kommula; Madugula, Sri Rama Murty

doi:10.1007/s13738-017-1107-z

Cited by 29 publications

(6 citation statements)

References 18 publications

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“…Kommula et al developed an efficient protocol for the synthesis of benzimidazole from 1,2-diamino benzenes and substituted aromatic aldehydes using a nano-Fe 2 O 3 catalyst (10 mol%). 83 Short reaction times, high efficiency, aqueous reaction medium, and recyclability of the catalyst are the main advantages of the synthesis ( Scheme 14 ).…”

Section: Benzimidazole Synthesis By Condensation Of 12-benzenediamine...mentioning

confidence: 99%

Recent achievements in the synthesis of benzimidazole derivatives

Chung,

Dung,

Duc

2023

RSC Adv.

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Section: Benzimidazole Synthesis By Condensation Of 12-benzenediamine...mentioning

confidence: 99%

Recent achievements in the synthesis of benzimidazole derivatives

Chung,

Dung,

Duc

2023

RSC Adv.

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“…Similarly, Kommula et al . have reported nano‐Fe 2 O 3 catalyzed synthesis of 2‐arylbenzimidazoles ( 13 ) by the reaction of o ‐phenylenediamine ( 4 ) with several aldehydes ( 12 ) in water using H 2 O 2 as mild oxidant . The reaction mixture was refluxed at 80°C for about 2–3 h, to give 70–85% yield (Scheme , Table , entry 2), whereas Bardajee et al .…”

Section: Nano‐transition Metal Catalyzed Oxidative Coupling Of O‐phenmentioning

confidence: 99%

“…Zamani et al also synthesized these benzimidazole derivatives (25) via reaction of aldehydes (24) with ophenylenediamines (4) from nano-TiCl 4 .SiO 2 as an efficient acidic and reusable catalyst [37]. The reaction took place in the absence of solvent at a temperature of 60°C and gave 82-98% product in just 4-8 min (Scheme 8, Table 3, entry 4).…”

Section: Other Transition Metal Nanocatalystsmentioning

confidence: 99%

Recent Trends in the Synthesis of Benzimidazoles From o‐Phenylenediamine via Nanoparticles and Green Strategies Using Transition Metal Catalysts

Singhal

Khanna

Panda

et al. 2019

Journal of Heterocyclic Chem

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Benzimidazole is a heterocyclic moiety of immense importance as it acts as a primary “biolinker” in diverse synthetic routes to obtain bioactive compounds. Substituted benzimidazoles are known to possess a varied range of pharmacological applications, namely, anti‐cancer, anti‐diabetic, anti‐inflammatory, and antiviral like anti‐HIV and anti‐fungal. A number of reviews covering the important aspects of benzimidazoles such as pharmacological activities, SAR studies, and well‐known methods of synthesis have appeared in the literature. However, green synthetic methods particularly using transition metal (TM) catalysts and their nanoparticles, although being more viable and extensively applied by researchers in the present scenario, have not been exclusively and expansively reviewed. Besides this, the vital precursors required for knitting the skeleton of benzimidazole are mainly o‐aryldiamines. The conventional synthesis generally involved the condensation of these diamines with carbonyl/carboxylic acid derivatives either via high temperature heating or via adding strong acids, mostly resulting in poor yields or mixtures. However, recent trends are replacing these conditions by mild and green conditions through TM catalysts. Therefore, the current review emphasizes on the recent trends adopted in the synthesis of benzimidazoles using condensation reaction of o‐phenylenediamines and various aldehydes/ester/amide/alcohols with TM in a catalytic role in nanoform and under environmentally benign green conditions.

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“…In addition, benzothiazole motifs are of outstanding significance due to their anticancer, antitumor, and antibacterial activities. [29] Several methodologies have been disclosed for the synthesis of benzothiazoles, such as SDS micelles, [29] nano-Fe 2 O 3 , [32] Bu t ONa, [33] and oxalic/malonic acid. [34] 2,3-dihydroquinazolin-4(1H)-ones (DHQs) are N-hetero bicyclic compounds that have wide-ranging application as drug intermediates in the pharmaceutical and biological fields.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MWCNTs‐ZrO₂ as a reusable heterogeneous catalyst for the synthesis of N‐heterocyclic scaffolds under green reaction medium

Halder

Banerjee

Nag

2020

Applied Organom Chemis

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A simple, efficient, and facile heterogeneous multi-walled carbon nanotubeszirconia nanocomposite (MWCNTs-ZrO 2) has been synthesized using natural feedstock coconut juice (água-de-coco do Ceará). The synthesized catalyst was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, and X-ray photoelectron spectroscopy analysis. The heterogeneous nanocomposite has been used for one-pot synthesis of various N-heterocyclic compounds like pyrazoles, 1,2-disubstituted benzimidazoles, 2-arylbenzazoles, and 2,3-dihydroquinazolin-4(1H)-ones under green reaction medium at room temperature. This novel method has several advantages, such as short reaction time, simple work-up, excellent yield, and green reaction conditions. The catalyst was recycled up to four times without significant loss in catalytic activity.

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Synthesis of benzimidazoles/benzothiazoles by using recyclable, magnetically separable nano-Fe2O3 in aqueous medium

Cited by 29 publications

References 18 publications

Recent achievements in the synthesis of benzimidazole derivatives

Recent achievements in the synthesis of benzimidazole derivatives

Recent Trends in the Synthesis of Benzimidazoles From o‐Phenylenediamine via Nanoparticles and Green Strategies Using Transition Metal Catalysts

MWCNTs‐ZrO₂ as a reusable heterogeneous catalyst for the synthesis of N‐heterocyclic scaffolds under green reaction medium

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Synthesis of benzimidazoles/benzothiazoles by using recyclable, magnetically separable nano-Fe2O3 in aqueous medium

Cited by 29 publications

References 18 publications

Recent achievements in the synthesis of benzimidazole derivatives

Recent achievements in the synthesis of benzimidazole derivatives

Recent Trends in the Synthesis of Benzimidazoles From o‐Phenylenediamine via Nanoparticles and Green Strategies Using Transition Metal Catalysts

MWCNTs‐ZrO2 as a reusable heterogeneous catalyst for the synthesis of N‐heterocyclic scaffolds under green reaction medium

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MWCNTs‐ZrO₂ as a reusable heterogeneous catalyst for the synthesis of N‐heterocyclic scaffolds under green reaction medium