Synthesis of benzimidazoles from o -phenylenediamines and DMF derivatives in the presence of PhSiH 3

Catalytic Reductive N‐Alkylations Using CO2 and Carboxylic Acid Derivatives: Recent Progress and Developments

“…Later, the group of Sakai described a general and effective method catalyzed by indium tribromide, where more than 25 alkyl amines were obtained in high yields by using different amides as the N‐alkylating sources (Scheme B) . In the same year, the groups of Liu and Sun reported an elegant catalyst‐free method for the synthesis of benzimidazoles by the N‐methylation of o ‐phenylenediamines with DMF derivatives and PhSiH 3 . More than 15 different compounds were obtained in good to excellent yields.…”

A nanoscopic icosahedral {Mo72Fe30} cluster catalyzes the aerobic synthesis of benzimidazoles

“…To show the merit of title methodology for the synthesis of 2aryl-1H-benzimidazole derivatives, the reaction conditions and the catalytic performance of a number of catalysts in literature, are summarized in Table 4 in comparison with this work. [35][36][37][38][39][40][41][42][43][44][45][46] Most of the catalysts given in Table 4, suffer seriously from toxicity and high catalyst dose. Additionally, they require toxic solvents and tedious work-up procedures or long reaction times.…”

Recent Uses of N,N-Dimethylformamide and N,N-Dimethylacetamide as Reagents

“…New metal-catalyzed and metal-free conditions involving the CH of the formyl group of DMF have been reported for cyclizations leading to heterocycles (Equations (69) [ 80 , 81 , 82 ] and (70) [ 83 ]).…”

“…2-Methylbenzimidazoles were obtained from PhSiH 3 -assisted delivery of the CMe of DMAc to benzene-1,2-diamines (Equation (71)) [ 82 ].…”