Synthesis of Bio-Compatible SPION–based Aqueous Ferrofluids and Evaluation of RadioFrequency Power Loss for Magnetic Hyperthermia

Mary, AP Reena; Narayanan, T N; Sunny, Vijutha; Sakthikumar, D.; Yoshida, Yasuhiko; Joy, P.A.; Anantharaman,

doi:10.1007/s11671-010-9729-4

Cited by 40 publications

(24 citation statements)

References 34 publications

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“…Raman spectroscopy was unable to give insights into the possible chemical structure alterations of the magnetic particles in these ferrofluids owing to the low concentration of magnetic nanoparticles. SQUID magnetometry measurements on the as prepared magnetic nanoparticles show an appreciable saturation magnetization comparable to that reported in literature . Room temperature measurements reveal that higher carrier fluid viscosity ferrofluids show lowered saturation magnetization.…”

Section: Discussionsupporting

confidence: 86%

Synthesis and Characterization of Magnetic Colloids

Pillai.S

Bhattacharya

2017

Macromolecular Symposia

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Magnetic fluids which constitute a suspension of magnetic nanoparticles in a carrier liquid are termed ferrofluids. Ferrofluids are smart fluids exhibiting both magnetic and fluid like characteristics. In the present study, we report on ferrofluidswhich are suspensions of magnetite (Fe3O4) nanoparticles in carrier fluids of varying viscosity. The magnetite nanoparticles have been synthesized by a chemical co‐precipitation method.X‐Raydiffraction of the as prepared sample revealsa single phase of magnetite.SEM characterisation reveals regular morphology and a narrow size distribution for the synthesized nanoparticles. These are dispersed in pure water and mixtures of water and glycerol using suitable surfactants and ultrasonicated. Our studies reveal that the stability of the ferrofluids have a strong dependence on the viscosity of the carrier fluid as well as the pH, with high viscosity and low pH yielding more stable ferrofluids. While low concentration of the magnetic component renders it impossible to see signatures of its presence in Raman spectroscopy, SQUID magnetometryreveals the presence of the magnetic component suggesting a distribution in size of the nanoparticles with a broad blocking temperature range. Further, a magnetic anomaly is seen at the freezing point of the carrier fluid in the ZFC‐FC measurements for the ferrofluid made with 50% v/v aqueous glycerol solution.

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Section: Discussionsupporting

confidence: 86%

Synthesis and Characterization of Magnetic Colloids

Pillai.S

Bhattacharya

2017

Macromolecular Symposia

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“…In an alternating magnetic field, the heat generation generally occurs due to the relaxation and hysteresis loss. Linear growth of the SAR values for uncovered SPIONs suggests the Brownian and Néel relaxation [39].…”

Section: Magnetic Hyperthermiamentioning

confidence: 94%

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

et al. 2020

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Iron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin®), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such nanoparticles to the specified tumor tissues. Systematic studies of Ho3+-doped bioconjugates were carried out as a preliminary step for future replacement of ‘cold’ Ho with 166Ho radionuclide, emitting ‘soft’ beta(-) radiation for possible targeted radionuclide therapy. Physicochemical properties of the obtained bioconjugates were subsequently tested for use in magnetic hyperthermia, considered as an effective, low-invasiveness anticancer therapy. With such a system we expect to achieve both: active targeting and multimodal action by simultaneous internal and localized irradiation and magnetic hyperthermia of specific cancers.

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“…Under such circumstances the particle as a whole rotates so as to align the easy axis in the magnetic field direction. The complex magnetic characteristics of nanofluids are attributed to both Brownian and Neel relaxation mechanisms [1,2]. The overall magnetic response of a nanoparticle suspended system depends on the particle properties, as well as the inter-particle interaction and the nature of the suspended medium.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear and magneto-optical transmission studies on magnetic nanofluids of non-interacting metallic nickel nanoparticles

Mary¹,

Sandeep²,

Narayanan³

et al. 2011

Nanotechnology

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Oxide free stable metallic nanofluids have the potential for various applications such as in thermal management and inkjet printing apart from being a candidate system for fundamental studies. A stable suspension of nickel nanoparticles of ∼ 5 nm size has been realized by a modified two-step synthesis route. Structural characterization by x-ray diffraction and transmission electron microscopy shows that the nanoparticles are metallic and are phase pure. The nanoparticles exhibited superparamagnetic properties. The magneto-optical transmission properties of the nickel nanofluid (Ni-F) were investigated by linear optical dichroism measurements. The magnetic field dependent light transmission studies exhibited a polarization dependent optical absorption, known as optical dichroism, indicating that the nanoparticles suspended in the fluid are non-interacting and superparamagnetic in nature. The nonlinear optical limiting properties of Ni-F under high input optical fluence were then analyzed by an open aperture z-scan technique. The Ni-F exhibits a saturable absorption at moderate laser intensities while effective two-photon absorption is evident at higher intensities. The Ni-F appears to be a unique material for various optical devices such as field modulated gratings and optical switches which can be controlled by an external magnetic field.

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Synthesis of Bio-Compatible SPION–based Aqueous Ferrofluids and Evaluation of RadioFrequency Power Loss for Magnetic Hyperthermia

Cited by 40 publications

References 34 publications

Synthesis and Characterization of Magnetic Colloids

Synthesis and Characterization of Magnetic Colloids

Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

Nonlinear and magneto-optical transmission studies on magnetic nanofluids of non-interacting metallic nickel nanoparticles

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