Synthesis of bioabsorbable networks from methacrylate-endcapped polyesters

Evaluation of an Injectable, Photopolymerizable, and Three-Dimensional Scaffold Based on Methacrylate-Endcapped Poly(D,L-Lactide-co-ɛ-Caprolactone) Combined with Autologous Mesenchymal Stem Cells in a Goat Tibial Unicortical Defect Model

“…24 Photopolymerizing materials used for bone reconstruction have promising characteristics: these products can be injected into a bone defect in moldable form and solidified in situ by exposure to a specific light source, maintaining the form and shape of the implant. [25][26][27][28][29][30][31] In the present study, photopolymerizable scaffolds based on D,L-lactide and ecaprolactone to encapsulate BMSC-loaded microcarriers were used in an experimental model for bone regeneration. Declercq et al demonstrated in a previous in vitro study that the encapsulated cells did not show pyknotic nuclei, pointing out that the photopolymerization and handling of the viscous polymer=microcarrier paste were not detrimental for the survival of the cells.…”

Synthesis, characterization and photopolymerization of vinyl functionalized poly (ε-caprolactone)

“…This assumption is valid if the testing material exhibiting single reaction without any other enthalpic events, such as evaporation of solvent or significant changes in heat capacity with conversion [16] (Equation (4)): (4) where dα/dt, the reaction rate [min -1 ]; α, the fractional conversion after time t; k (T) , temperature dependent rate coefficient [min -1 ]; n, m, reaction orders of propagation and initiation respectively. Second-order autocatalytic model was assumed by fixing (m + n = 2).Temperature dependent rate coefficient k (T) is assumed to follow the Arrhenius equation (Equation (5)): (5) where E a is the activation energy, A is the frequency factor, R is the ideal gas constant and T is the absolute temperature [K].…”

“…They degrade mainly by hydrolysis of ester linkages, yield hydroxyl carboxylic acids, which in most cases are ultimately metabolized [2]. The functionalization of oligomers such as ε-caprolactone, with unsaturated groups and subsequent Ultraviolet (UV) curing [3,4] or polymerization [5,6] has been studied. Especially, UV curing is interesting since it usually provides fast, well-controlled and low energy consumption process, capable of forming thin films or predefined patterns, and can be carried out at low temperatures [7].…”

“…It could be more convenient, if the vari-able rate of degradation is obtained by formation of multilayered polymeric coatings, by rapid and wellcontrolled UV curing. Photo-curable functional groups, such as methacrylates have been used most often as unsaturated group attached on precursor oligomers [4][5][6]. Functionalization with coumarin and phenylazide has been reported as well [12,13].…”

Síntesis, caracterización y aplicaciones biomédicas de redes de copolímeros basados en poliésteres.

“…Los poli(α-hidroxi ácidos) provenientes de acrilatos y metacrilatos han sido preparados mediante la funcionalización de oligómeros terminados en grupos hidroxilos haciéndolos reaccionar con diferentes cloruros de ácidos [93][94][95][96][97][98] o por transesterificación de PDLLA de alto peso molecular con diacrilatos [99].…”