Synthesis of Bioactive 4-Oxo-4H-Chromenes Bearing Heterocyclic Systems from Hydrazonecarbodithioic Acid and Thiocarbohydrazone

Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1,2,4-triazoles, 1,2,4-triazines and 1,2,4-triazepines ring systems

“…Oxidation of the latter compound by ferric chloride in boiling DMSO yielded 2,7-bis(6-chloro-4-oxo-4H-chromen-3-yl)-5-oxo-1,5-dihydro-1,2,4-triazolo [1,5-a] pyridine-6,8-dicarbonitrile (9). Compound 9 was also obtained by refluxing 4 with 6-chloro-chromone-3-carboxylic acid (8) in phosphorus oxychloride (Scheme 3). The analytical and spectral data of 7 and 9 are in agreement with the proposed structures.…”

“…In continuation to our interest in the synthesis of chromone derivatives containing nitrogen heterocyclic systems, 7,8,23 compound 4 was allowed to react with some chromone derivatives. Thus, cyclocondensation of 4 with 6-chloro-3-formylchromone (1) in DMF under reflux containing few drops of piperidine afforded the 1,2,3,5-tetrahydro [1,2,4] triazolo [1,5-a]pyridine derivative 7.…”

3-Formylchromones as diverse building blocks in heterocycles synthesis

“…Also, condensation of 1c with two equivalents of thiocarbohydrazide gave bis thiocarbohydrazone derivative 238 (Scheme111) [173].…”

Synthesis and antimicrobial activity of some new 1,3-thiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and 1,3-thiazines incorporating acridine and 1,2,3,4-tetrahydroacridine moieties

“…In view of the above mentioned findings and in continuation of our efforts [27][28][29] to identify new candidates that may be of value in designing new and potent antimicrobial agents, we decided in the present work to synthesize new 1,3-thiazole, 1,3,4-thiadiazole, 1,2,4-triazole and 1,3-thiazine derivatives bearing acridine and 1,2,3,4-tetrahydroacridine moieties in order to investigate their antimicrobial activities.…”