Synthesis of Bioactive Heterocycles Exploiting Modern Continuous Flow Chemistry

Baumann, Marcus

doi:10.1002/9781119757153.ch12

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2023

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Cited by 2 publications

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“…For example, biologically active natural compounds, synthetic pharmaceuticals, and smart materials all contain nitrogen-containing aromatic motifs, making them privileged scaffolds. 6 The development of homogeneous catalysts towards the preparation of unsaturated N -heteroarenes by a dehydrogenation reaction was pioneered by Yamaguchi and Fujita using an iridium catalyst. 7 Further developments by Crabtree, 8 Fischmeister, 9 and Albrecht 10 also employed different iridium-based homogeneous catalysts.…”

Section: Introductionmentioning

confidence: 99%

Photochemical oxidative dehydrogenation of saturated N-heterocycles by an iminoquinone

Mandal,

Bains,

Roy

et al. 2023

Catal. Sci. Technol.

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Section: Introductionmentioning

confidence: 99%

Photochemical oxidative dehydrogenation of saturated N-heterocycles by an iminoquinone

Mandal,

Bains,

Roy

et al. 2023

Catal. Sci. Technol.

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Catalytic Enantioselective Synthesis Enabled by Electrochemistry

Phillips

Pombeiro

2023

Synthesis

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Catalytic enantioselective electrochemical synthesis has emerged in recent years as an efficient, clean, sustainable way to obtain chiral, non-racemic molecules. The difficulties in finding reaction conditions that are compatible with the delicate functional groups of many chiral ligands and organocatalysts has hampered the developments in this field. However, the fact that very minute differences in potential can be selected, allows for fine-tuning, so that very high chemoselectivities can be achieved, which is attracting much attention. Although still few in number compared to other areas of knowledge, the existing methods allow a variety of bond-forming reactions to be performed, and very high yields and ees can be achieved. The present review surveys the literature published in the last four years. 1. Introduction 2. Transition metal catalyzed reactions 2.1 Alkylation by C-H bond functionalization: C(sp3)-C(sp3) bond formation 2.2 C(sp3)-C(sp2) bond formation 2.2.1 Alkene functionalization by cross-coupling reactions 2.2.2 Arylation by cross-coupling reactions 2.3 Alkynylation: C(sp3)-C(sp) bond formation 2.4 Cross-coupling reactions for the synthesis of axially chiral biaryls 2.5 Cyanofunctionalization 2.6 Miscellaneous 3. Organocatalysis 4. Conclusions

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Synthesis of Bioactive Heterocycles Exploiting Modern Continuous Flow Chemistry

Cited by 2 publications

References 76 publications

Photochemical oxidative dehydrogenation of saturated N-heterocycles by an iminoquinone

Photochemical oxidative dehydrogenation of saturated N-heterocycles by an iminoquinone

Catalytic Enantioselective Synthesis Enabled by Electrochemistry

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