Synthesis of bioactive quinoline acting as anticancer agents and their mode of action using in silico analysis towards Aurora kinase A inhibitors

Quinoline has recently become an important heterocyclic molecule due to its numerous industrial and synthetic organic chemistry applications. Quinoline derivatives have been used in clinical trials for a variety of medical conditions that causes cancer. The present literature study is composed of recent progress (mainly from 2010 to the present) in the production of novel quinoline derivatives as potential anti-cancer agents, as well as their structure-activity relationship, which will provide insight into the development of more active quinoline hybrids in the future. The present review comprises the synthetic protocols of biologically active Quinoline analogs with their structure-activity relationship studies as anti-cancer agents, which provide depth view of work done on quinoline derivatives to the medicinal chemist for future research

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Synthesis of bioactive quinoline acting as anticancer agents and their mode of action using in silico analysis towards Aurora kinase A inhibitors

Cited by 4 publications

References 28 publications

Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity

Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity

A comprehension on synthetic strategies of Aurora kinase A and B inhibitors

Synthesis and SAR of Potential Anti-Cancer Agents of Quinoline Analogues: A Review

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