Synthesis of biodegradable Zn-based scaffolds using NaCl templates: Relationship between porosity, compressive properties and degradation behavior

Hou, Yi; Jia, Gaozhi; Yue, Rongcai; Chen, Chenxin; Jia, Pei; Zhang, Hua; Huang, Hua; Xiong, Meiping; Yuan, Guangyin

doi:10.1016/j.matchar.2018.01.033

Cited by 66 publications

(33 citation statements)

References 48 publications

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“…Additionally, Capek et al [126] observed that sintered Zn made of coarse powder exhibited better compressive properties than those made of fine powder due to a lower volume of porosity. Hou et al [127] noted that increasing porosity content lowers the compressive strength of both Zn and Zn-3Cu, as seen in Table 3. This is consistent with other reports that describe the negative influence of porosity on the mechanical properties of 3D printed Zn [79,80].…”

Section: Influence Of Fabrication Techniquementioning

confidence: 93%

“…An average porosity of about 20% was measured in the final product. Hou et al [127] used hot press sintering (HPS) of salt (NaCl) templates followed by pressure infiltration casting to create porous biodegradable Zn-scaffolds. The produced scaffolds were hierarchical, open porous structure consisting of central and interconnected pores, and with porosity volume of up to 75%.…”

Section: Advanced Processing Techniquesmentioning

confidence: 99%

“…Alloying appears to be similarly effective in improving the mechanical strength of porous Zn constructs. For example, Hou et al [127] noted that adding Cu improved the compressive strength of porous Zn, even at 68% and 75% porosity volumes.…”

Section: Influence Of Alloying Elementsmentioning

confidence: 99%

“…The powder process can be used for fabricating (i) fully Table 3. dense components [113], (ii) components with tunable porosities [126], and even (iii) metal-matrix composites (MMC) [128]. Porous Zn can also be created using NaCl as a space holder [127]. However, when adopting these techniques, the user needs to recognize the adverse influence of porosities on the mechanical properties of its products.…”

Section: Influence Of Fabrication Techniquementioning

confidence: 99%

“…The biodegradability of porous Zn is also of interest, especially if the metal is considered for tissue-engineered bone scaffold applications [175]. Hou et al [127] observed an increase in the biodegradability of porous Zn with an increasing specific area of porosities. This is reasonable since corrosion attack is expected to initiate at any exposed surfaces on the metal [169] (i.e., in the case of porous Zn, this refers not only to the external surface but also to the surfaces of the interconnected pores).…”

Section: Influence Of Fabrication Techniquementioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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Zinc has been identified as one of the most promising biodegradable metals along with magnesium and iron. Zinc appears to address some of the core engineering problems associated with magnesium and iron when applied to biomedical implant applications; hence the increase in the amount of research investigations on the metal in the last few years. In this review, the current state-of-the-art on biodegradable Zn, including recent developments, current opportunities and future directions of research are discussed. The discussions are presented with a specific focus on reviewing the relationships that exist between mechanical properties, biodegradability, and biocompatibility of zinc with alloying and fabrication techniques. This work hopes to guide future studies on biodegradable Zn that will help in advancing this field of research. Statement of Significance (i) The review offers an up-to-date and comprehensive review of the influence of alloying and fabrication technique on mechanical properties, biodegradability and biocompatibility of Zn; (ii) the work cites the most relevant biodegradable Zn fabrication processes including additive manufacturing techniques; (iii) the review includes a listing of research gap and future research directions for the field of biodegradable Zn.

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Section: Influence Of Fabrication Techniquementioning

confidence: 93%

Section: Advanced Processing Techniquesmentioning

confidence: 99%

Section: Influence Of Alloying Elementsmentioning

confidence: 99%

Section: Influence Of Fabrication Techniquementioning

confidence: 99%

Section: Influence Of Fabrication Techniquementioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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Mechanical and Degradation Behavior of Zinc‐Based Biodegradable Metal Foams

Kádár,

Gorejová,

Kubelka

et al. 2024

Adv Eng Mater

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Zinc has gained interest as a biodegradable material due to its adequate degradation behavior under physiological conditions and acceptable biocompatibility. However, during the use of zinc as a degradable orthopedical implant, the mechanical properties are expected to change while the implant needs to maintain its function and mechanical support for 12‐24 months, with the load gradually transferred from the degrading implant to the healing bone. For such investigation, six different kinds of open‐cell zinc foams are fabricated by a modified investment casting method displaying different pore densities and strut thicknesses. Compressive properties and corrosion behavior in simulated body fluids are studied to determine the map of the most relevant parameters that influence the degradation properties. After 4 weeks of immersion in Hank’s solution, changes in the slope in the “plateau” region and strain localization are observed. These changes can be explained by supposing microcrack propagation into the depth of the struts due to the progressing corrosion attack.This article is protected by copyright. All rights reserved.

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The Prospects for Biodegradable Zinc in Wound Closure Applications

Venezuela

Johnston

Dargusch

2019

Adv Healthcare Materials

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Zinc is identified as a promising biodegradable metal along with magnesium and iron. In the last five years, considerable progress has been made on understanding the mechanical properties, biodegradability, and biocompatibility of zinc and its alloys. A majority of these studies focused on using zinc for absorbable cardiovascular and orthopedic device applications. However, it is likely that zinc is also suitable for other biomedical applications.In this work, the prospects for zinc in the fabrication of wound closure devices such as absorbable sutures, staples, and surgical tacks are critically assessed, with the aim of inspiring future research on biodegradable Zn for this medical application.

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Synthesis of biodegradable Zn-based scaffolds using NaCl templates: Relationship between porosity, compressive properties and degradation behavior

Cited by 66 publications

References 48 publications

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

Mechanical and Degradation Behavior of Zinc‐Based Biodegradable Metal Foams

The Prospects for Biodegradable Zinc in Wound Closure Applications

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