Synthesis of biologically active compounds based on 2-ferrocenylmethylene-3-quinuclidone

Synthesis of ferrocenylpyrazole derivatives

“…2-Ferrocenylmethylidenetetralones 3a-f were prepared by condensation of ferrocenecarbaldehyde with tetralones in aqueousethanolic alkali [11]. The physical and 1 H NMR spectroscopic characteristics of compounds 1a-f and 3a-f were in accord with the literature data [8][9][10][11].…”

“…These were prepared by condensation of acetylferrocene with arenecarbaldehydes in aqueous-ethanolic alkali [8][9][10]. 2-Ferrocenylmethylidenetetralones 3a-f were prepared by condensation of ferrocenecarbaldehyde with tetralones in aqueousethanolic alkali [11].…”

Synthesis and Some Chemical Transformations of (Z)‐ and (E)‐2‐Acetyl‐1‐ferrocenyl‐3‐methylbuta‐1,3‐dienes − A New Type of Cationic Cycloaddition

“…[12,15] Stepwise, non-synchronous mechanisms have been proven experimentally [16,17] for the proton-induced cyclodimerization and cationic cycloaddition, which are essential from a theoretical point of view.…”

“…[14] Ferrocenyl-, (aryl)ferrocenyl-, (alkyl)ferrocenyl-, (alkyl)diferrocenyl-and (aryl)diferrocenylbuta-1,3-dienes have been reported; their thermal and proton-induced cyclodimerization [9,11] and cationic cycloaddition [10,12] reactions occur with high diastereoselectivity. The reaction products comprise alkylaryl(ferrocenyl)-substituted six-membered carbocycles that are either free or fused to other carbo-or heterocyclic systems.…”

Reaction of monocyclic ferrocenyl-4,5-dihydropyrazoles with β-dicarbonyl compounds

“…A series of stable dihydropyrazoles containing a ferrocenyl substituent and a substituent on N 1 are found to possess biological activity. In detail, 4-acetyl-3-ferrocenyl-1,4,5-triazatricyclo[5.2.2.0 2.6 ]undec-5-ene exhibits a high antiviral activity [9]. Introduction in ferrocenyl-4,5-dihydropyrazole of additional carbo-and heterocyclic fragments, as well as various substituents on the N 1 atom of the pyrazole ring permits one to expect a broader spectrum of useful properties in the resulting products.…”