Synthesis of Biologically Active α-Aminophosphonates

Abstract

Highly convergent Synthesis of-aminophosphonates were most conveniently achieved using organophosphorus chemistry. Synthesis of-aminophosphonates were accomplished by three-component coupling of carbonyl, amine and hydrophosphoryl compounds. These aminophosphonates exhibited promising antimicrobial, antioxidant and anticancer activity. Some recent developments and applications to the synthesis of biologically activeaminophosphonates are also included.

Microwave‐Assisted One‐Pot Synthesis of New α‐Aminophosphonates Using ZnBr2‐SiO2 as a Catalyst under Solvent‐Free Conditions and Their Anticancer Activity

“…The synthesis of α-aminophosphonates pulled in much intrigue on account of their profile action and auxiliary similarity to αamino acids. [1][2][3] They resembles like enzyme inhibitors, [4] haptens of synergist antibodies, [5] anti-toxins and pharmacological agents [6] and the analogues of amino acids. The aminophosphonic, and aminophosphinic acids are of extensive enthusiasm because of their properties in agrochemistry as plant growth regulators and herbicides.…”

Practical synthesis of novel phosphonopeptides containing AibP

“…α ‐Aminophosphonates are probably the most important analogs of the corresponding α ‐amino acids in biological systems, because these compounds are considered as stable mimetics of the tetrahedral transition state of peptide hydrolysis ; therefore, these compounds have wide applications in medicinal, bioorganic, agricultural, and organic synthesis . For example, the α ‐aminophosphonates of type 1 and derivatives have been evaluated as carriers of hydrophilic organic molecules across phospholipid membranes , and the α ‐aminophosphonate bearing a triphenylphosphonium bromine 2 has been used as nontoxic, poorly metabolizable, specific, and sensitive 31 P NMR probe for mitochondrial pH determination .…”