Synthesis of bioreducible core crosslinked star polymers with N,N′-bis(acryloyl)cystamine crosslinker via aqueous ethanol dispersion RAFT polymerization

Star polymers with acid-labile diacetal-based cores synthesized by aqueous RAFT polymerization for intracellular DNA delivery

“…58,59 Howeve r, these studies were performed either in organic solvents (acetonitrile), 58 and/or high polymeriza tion temperatures (70 °C) 58,59 and/or long reaction times (24 h). An and coworkers , 59 -63 Wang et al, 64 Tucker et al 65 and more recently Chen et al 66 used a more biologically-f riendl y methodol ogy, RAFT heterogeneous emulsion and dispersion polymerizati on in water or water/alcohol mixtures, to prepare star polymers wi th low Ð values in high yields and high solid content. This syntheti c methodol ogy appears to be promising for the development of highly biocompa tibl e star polymer vehicles for nucleic aci d delivery.…”

Synthesis, Characterization and Cytotoxicity of Novel Thermoresponsive Star Copolymers of N,N′-Dimethylaminoethyl Methacrylate and Hydroxyl-Bearing Oligo(Ethylene Glycol) Methacrylate

“…Star polymers with arms consisting of N , N -dimethylaminoethyl methacrylate and oligo(ethylene glycol) methacrylate (OEGMA) with different numbers of ethylene glycol units could be synthesized using different polymerization techniques, e.g., ATRP [9,10,11,12], reversible addition-fragmentation chain transfer (RAFT) [13,14] or group transfer polymerization (GTP) [15]. Both the “core first” and “arm first” approaches have been used to synthesize these structures by the aforementioned polymerizations.…”

From non-conventional ideas to multifunctional solvents inspired by green chemistry: fancy or sustainable macromolecular chemistry?

“…In search of widely available and low-cost reducing factors, a group of compounds, namely alcohols, commonly used in laboratory work, were investigated as their structures suggest strong reducing properties. Additionally, some of them have already been used as RDRP solvents, 15,25,48,186,187 thus possibility of their application in a dual role might significantly simplify the process. First of all, poly(ethylene glycol) (PEG) is a subject of increasing attention on account of its low toxicity, biocompatibility, 188 and ability to play various roles in ATRP mechanisms such as solvent, ligand due to numerous lone electron pairs 188 or reducing factors through the oxidation of hydroxyl groups.…”