2007
DOI: 10.1002/ejoc.200600764
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Synthesis of Both Enantiomers of Conduritol C Tetraacetate and of meso‐Conduritol D Tetraacetate by Oxidation of Benzoquinone Bis(ethylene acetal)

Abstract: Epoxidation of p‐benzoquinone bis(ethylene acetal) (1) with m‐chloroperbenzoic acid or hydrogen peroxide/benzonitrile afforded corresponding monoepoxide 2, which was converted into p‐benzoquinone mono(ethylene acetal) monoepoxide 5 with perchloric acid. Dihydroxylation of 1 with osmium tetroxide or ruthenium trichloride/sodium periodate afforded corresponding cis‐diol 6, which was subsequently acetylated to give diacetate 7. One ethyleneacetal moiety in 7 could be selectively hydrolyzed with silica gel/ferric … Show more

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Cited by 10 publications
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“…These conditions were particularly successful for substrates that were difficult to oxidise with OsO 4 . 7 In recent years, Plietker has investigated the oxidation with RuO 4 and attempted to circumnavigate the different issues linked to the use of RuO 4 (over-oxidation/oxidative cleavage). 8 Mechanistic studies of the dihydroxylation led to the conclusion that the turnover-limiting step is the hydrolysis of the intermediate ruthenate ester (Fig.…”
Section: Ruthenium-mediated Syn-dihydroxylationmentioning
confidence: 99%
“…These conditions were particularly successful for substrates that were difficult to oxidise with OsO 4 . 7 In recent years, Plietker has investigated the oxidation with RuO 4 and attempted to circumnavigate the different issues linked to the use of RuO 4 (over-oxidation/oxidative cleavage). 8 Mechanistic studies of the dihydroxylation led to the conclusion that the turnover-limiting step is the hydrolysis of the intermediate ruthenate ester (Fig.…”
Section: Ruthenium-mediated Syn-dihydroxylationmentioning
confidence: 99%