Synthesis of branched polynuclear 1,3,4-oxadiazoles

Abstract

The reaction of 5-substituted mono-and polytetrazoles with heterocyclic acid chlorides and trifluoroacetic acid anhydride gave branched polynuclear 1,3,4-oxadiazole systems.In searches for novel photosensitive [1] and biologically active materials [2-4] a broad series of 1,3,4-oxadiazoles with different substituents on the carbon atoms have been reported. The usual basis for their synthesis is mainly the dehydration of the corresponding acid hydrazides [5]. However, this reaction is done in relatively severe conditions and does not permit preparation of polynuclear systems with different proportions of oxadiazole rings and other heterocycles as substituents on the oxadiazoles. To a certain extent this restriction is N N N N

Synthesis of polynuclear heterocyclic polynitrogen systems based on cyanuric chloride and its derivatives

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Polynuclear structures containing several heterocycles of various types were synthesized by the reaction of cyanuric chloride and its mono-and dichloro derivatives with triazoles and tetrazoles in the presence of bases.In our earlier papers we demonstrated the fundamental possibility of the synthesis of noncondensed polynuclear triazole-and tetrazole-containing units by the gradual insertion of new heterocycles into the initial azole [1,2]. In a continuation of these investigations in the present work we have examined a version of the synthesis of polynuclear structures based on the molecules of cyanuric chloride (1), 2-chloro-4,6-dimethoxy-1,3,5-triazine (2), 2-chloro-4,6-dimorpholino-1,3,5-triazine (3), 2,4-dichloro-6-methoxy-1,3,5-triazine (4), and 2,4-dichloro-6-diethylamino-1,3,5-triazine (5).

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