Synthesis of Brush‐Like Glycopolymers with Monodisperse, Sequence‐Defined Side Chains and Their Interactions with Plant and Animal Lectins

Shamout, Fadi; Monaco, Alessandra; Yilmaz, Gökhan; Becer, C. Remzi; Hartmann, Laura

doi:10.1002/marc.201900459

Cited by 19 publications

(15 citation statements)

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“…[ 237,238 ] Similar outcomes were established with locally monodisperse structures (i.e., in the side chain) that were carried out on brush like glycopolymers. [ 231 ]…”

Section: Applications Of Discrete Synthetic Macromolecules In Life Scmentioning

confidence: 99%

Applications of Discrete Synthetic Macromolecules in Life and Materials Science: Recent and Future Trends

et al. 2021

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In the last decade, the field of sequence‐defined polymers and related ultraprecise, monodisperse synthetic macromolecules has grown exponentially. In the early stage, mainly articles or reviews dedicated to the development of synthetic routes toward their preparation have been published. Nowadays, those synthetic methodologies, combined with the elucidation of the structure–property relationships, allow envisioning many promising applications. Consequently, in the past 3 years, application‐oriented papers based on discrete synthetic macromolecules emerged. Hence, material science applications such as macromolecular data storage and encryption, self‐assembly of discrete structures and foldamers have been the object of many fascinating studies. Moreover, in the area of life sciences, such structures have also been the focus of numerous research studies. Here, it is aimed to highlight these recent applications and to give the reader a critical overview of the future trends in this area of research.

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“…[ 237,238 ] Similar outcomes were established with locally monodisperse structures (i.e., in the side chain) that were carried out on brush like glycopolymers. [ 231 ]…”

Section: Applications Of Discrete Synthetic Macromolecules In Life Scmentioning

confidence: 99%

Applications of Discrete Synthetic Macromolecules in Life and Materials Science: Recent and Future Trends

et al. 2021

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“…In addition to the screened or designed binding capability of SDPs, well-studied affinity ligands have also been incorporated into precise SDP scaffolds, providing another approach to create precision binding ligands. In this aspect, Hartmann and co-workers − developed a set of precise saccharide-conjugated polymers with binding affinities toward diverse lectins and proteins. For instance, an array of highly sulfated, glycomimetic precise oligomers and polydisperse polymers with different chain lengths were created, serving as potent inhibitors of viral binding/infection .…”

Section: Sdp-based Functional Biomaterialsmentioning

confidence: 99%

Sequence-Defined Synthetic Polymers for New-Generation Functional Biomaterials

Deng

Shi

Tan

et al. 2021

ACS Materials Lett.

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Synthetic polymers have been extensively exploited for biomedical and pharmacological applications, spanning from surgical devices, diagnostics, tissue engineering, regenerative medicine, to drug delivery systems. However, a fundamental and quantitative correlation between the primary chemical structures of polymeric biomaterials and the resulting biological responses remains elusive. Encouragingly, the advent and development of sequence-defined polymers (SDPs) provide an unprecedented opportunity to precisely tune their sequence information, intrachain folding, interchain self-assembly, and macroscopic properties, enabling the elucidation of the structure–property relationship of biomaterials. In this Perspective, we highlight recent advances of SDPs as next-generation functional biomaterials, and their potential applications in antimicrobial agents, bioactive ligands, precision drug delivery systems, bioimaging agents, and barcoded biomaterials, from sequence-defined synthetic oligomers and polymers. Finally, we present a critical outlook on the challenges in the design and development of SDP-based emergent biomaterials.

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“…through polyaddition or grafting-to strategies. 20,21 Inspired by the work on peptide amphiphiles, here we explore the possibility to use precision glycomacromolecules as head groups in tailor-made amphiphiles and generate self-assembly structures with potential bioactivity.…”

Section: Introductionmentioning

confidence: 99%