Synthesis of Ca-doped ZnO nanoparticles and its application as highly efficient electrochemical sensor for the determination of anti-viral drug, acyclovir

Ilager, Davalasab; Shetti, Nagaraj P.; Malladi, Ramesh S.; Shetty, Nitinkumar S.; Reddy, Kakarla Raghava; Aminabhavi, Tejraj M.

doi:10.1016/j.molliq.2020.114552

Cited by 76 publications

(21 citation statements)

References 56 publications

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“…In general, most of the methodologies in the literature describes HCQ detection and quantification by chromato-graphic, spectrophotometric, and coupled techniques [9][10][11], by which, although these methods are accurate, they show some disadvantages such as extended analysis time, which also contributes to the more significant production of chemical residues. Nevertheless, electrochemical methods [8,12,13] can be easily operated, requiring lower-cost equipment, showing high sensitivity and precision, and quick response, which makes them advantageous compared to these methods [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A Novel Carbon Nitride Nanosheets‐based Electrochemical Sensor for Determination of Hydroxychloroquine in Pharmaceutical Formulation and Synthetic Urine Samples

Silva

Sant’Anna

Gevaerd³

et al. 2021

Electroanalysis

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This study introduces modified carbon paste electrodes with carbon nitride nanosheets (CNNS) and outlines their application for the determination of hydroxychloroquine sulfate (HCQ) in tablets and synthetic urine samples. CNNS were synthesized by hydrothermal route (200°C, 10 h) using melamine and citric acid as their precursors. The carbon nitride nanosheets-based electrode (CNNS/E) presented a linear dynamic range for HCQ (LDR), ranging from 10.0 nmol l À 1 to 6.92 μmol l À 1 , and detection (LOD) and quantification limits (LOQ) of 0.16 nmol l À 1 and 0.52 nmol l À 1 , respectively. LOD and LOQ were calculated by the equations: LOD = 3(S d /b), and LOQ = 10(S d /b). The modified sensor presented excellent relative standard deviations for parameters such as repeatability (2.39 % and 1.87 %) and reproducibility (3.22 % and 2.32 %) in HCQ oxidation peaks (1 and 2). The CNNS/E has not shown significant variations in its anodic signal intensity in the presence of some organic and inorganic substances. It is worth bearing in mind that CNNS/E can be easily manufactured and the sensor has the lowest HCQ detection limits reported so far. The proposed sensor was successfully applied for HCQ determination in tablets and synthetic urine, showing good recovery values and an error of 0.60 % about comparative method in tablet samples, assuring the quality of the method.

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Section: Introductionmentioning

confidence: 99%

A Novel Carbon Nitride Nanosheets‐based Electrochemical Sensor for Determination of Hydroxychloroquine in Pharmaceutical Formulation and Synthetic Urine Samples

Silva

Sant’Anna

Gevaerd³

et al. 2021

Electroanalysis

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“…A recent study reported that the Ca-doped ZnO nanoparticles used in electrochemical sensors showed significant sensitivity, selectivity, and reproducibility, owing to the increased surface area in the doped ZnO [ 82 ]. Another study evaluated different concentrations of Ca (as a dopant) used to modify the crystalline structure of the ZnO films in Love wave sensors, confirming an increase in sensitivity due to the increase in the surface roughness after the addition of Ca [ 83 ].…”

Section: Experimental Studiesmentioning

confidence: 99%

Recent Advances in ZnO-Based Carbon Monoxide Sensors: Role of Doping

Pineda-Reyes

Herrera-Rivera

Rojas-Chávez

et al. 2021

Sensors

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Monitoring and detecting carbon monoxide (CO) are critical because this gas is toxic and harmful to the ecosystem. In this respect, designing high-performance gas sensors for CO detection is necessary. Zinc oxide-based materials are promising for use as CO sensors, owing to their good sensing response, electrical performance, cost-effectiveness, long-term stability, low power consumption, ease of manufacturing, chemical stability, and non-toxicity. Nevertheless, further progress in gas sensing requires improving the selectivity and sensitivity, and lowering the operating temperature. Recently, different strategies have been implemented to improve the sensitivity and selectivity of ZnO to CO, highlighting the doping of ZnO. Many studies concluded that doped ZnO demonstrates better sensing properties than those of undoped ZnO in detecting CO. Therefore, in this review, we analyze and discuss, in detail, the recent advances in doped ZnO for CO sensing applications. First, experimental studies on ZnO doped with transition metals, boron group elements, and alkaline earth metals as CO sensors are comprehensively reviewed. We then focused on analyzing theoretical and combined experimental–theoretical studies. Finally, we present the conclusions and some perspectives for future investigations in the context of advancements in CO sensing using doped ZnO, which include room-temperature gas sensing.

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“…Moreover, the anodic peak potential (E pa ) obtained at PLSMCPE (0.206 V) is lower than that of obtained at BCPE (E pa = 0.416 V), indicating that the polymer film on the electrode surface accelerates the electron transfer. The electrochemical surface area of BCPE and PLSMCPE was calculated using the Randles-Sevcik equation; [27,28]…”

Section: Assessment Of Electroactive Surface Areamentioning

confidence: 99%

Efficient Electrochemical Determination of Catechol with Hydroquinone at Poly (L‐Serine) Layered Carbon Paste Electrode

et al. 2021

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The current endeavour presents the poly(L-serine) modified carbon paste electrode (PLSMCPE) fabricated through an electropolymerization methodology for the electrochemical analysis of catechol (CC). Field emission scanning electron microscopy (FE-SEM) images of unmodified and PLSMCPE were examined to study the surface structure and the formation of polymer layer on the electrode surface. The PLSMCPE was functionalized for the voltammetric detection and quantification of CC in 0.2 M phosphate buffer solution (PBS) with a pH of 6.5. In contrast to unmodified electrode the PLSMCPE presented to have nine-fold enhancement in peak current and shift in anodic peak potential towards negative domain. The CV method showed good linear correlation between the concentration of CC and the oxidation peak current in the range from 2-50 μM, and the corresponding limit of detection (LOD) and limit of quantification (LOQ) were achieved to be 0.259 μM and 0.869 μM, respectively. Furthermore, this sensor is used to determine the analytical response in the co-existence of CC and hydroquinone (HQ). The modified electrode is effectively functionalised for the analysis of CC in coffee powder sample.

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Synthesis of Ca-doped ZnO nanoparticles and its application as highly efficient electrochemical sensor for the determination of anti-viral drug, acyclovir

Cited by 76 publications

References 56 publications

A Novel Carbon Nitride Nanosheets‐based Electrochemical Sensor for Determination of Hydroxychloroquine in Pharmaceutical Formulation and Synthetic Urine Samples

A Novel Carbon Nitride Nanosheets‐based Electrochemical Sensor for Determination of Hydroxychloroquine in Pharmaceutical Formulation and Synthetic Urine Samples

Recent Advances in ZnO-Based Carbon Monoxide Sensors: Role of Doping

Efficient Electrochemical Determination of Catechol with Hydroquinone at Poly (L‐Serine) Layered Carbon Paste Electrode

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