Synthesis of carbon‐14 analogue of N‐(1‐methyl‐2‐oxo‐5‐phenyl‐2,3‐dihydro‐1H‐benzo[e][1,4]diazepin‐3‐yl)‐benzamide‐[carboxyl‐¹⁴C] as CCK‐A antagonist

Abstract

N‐(1‐methyl‐2‐oxo‐5‐phenyl‐2,3‐dihydro‐1H‐benzo[e][1,4]diazepin‐3‐yl)‐benzamide‐[carboxyl‐14C] has been synthesized from benzonitrile‐[cyano‐14C]. Copyright © 2005 John Wiley & Sons, Ltd.

Strategy for 14C‐labeling of a series of bis(heteroaryl)piperazines

“…In this approach, according to the synthetic pathway shown in Scheme , potassium [ 14 C]‐thio‐cyanate 5 was obtained quantitatively via the reaction between potassium [ 14 C] cyanide 4 and sulfur in acetone 12, 13…”

Fast and efficient synthesis of 14C labelled benzonitriles and their corresponding acids

“…Synthesis of 14 C labelled anthranilic acid (3) has been reported in the literature 1,14,15 which requires special equipment for handling. In all reported methods more than one equivalent of 14 C precursor was used.…”

Synthesis of 1‐(1‐benzyl‐2‐ethylthio‐2‐14C‐5‐imidazolyl)‐4‐[3‐(1‐isopropylamino)‐2‐pridyl] piperazine

“…4 In this paper, the synthesis 7 Subsequent alkylation of compound 7 with ethyl iodide and oxidation of the product with manganese dioxide and further oxidation of the latter product with alkaline solution of silver nitrate gave [2-14 C]-2-ethylthio-1-benzylimidazole-5-carboxylic acid 8.…”