Synthesis of carbon‐14 labelled gemifloxacin

Abstract

SummaryA new antibacterial agent gemifloxacin was labelled with carbon-14 for studies of pharmacokinetics and metabolism, the label was located in position 3 of the quinolone ring system. The overall radiochemical yield of the 14-step synthesis, starting from [2-14 C]sodium acetate was 16.6%, and the radiochemical purity 97.5%.