Wastes are produced at large amounts all over the world. These wastes cause a variety of problems to the ecosystem, plants, animals, and humans. In this chapter, we discuss the wastes, types of wastes, sources of wastes, and problems related to wastes, especially health-related problems. Then we discuss agricultural wastes and how we can synthesize different nanoparticles from them. Also, we discuss industrial wastes and different nanoparticles synthesized from them. Additionally, we discuss fruit wastes and production of different nanoparticles and also food wastes and their uses in nanoparticle syntheses. Also, we can use other wastes to produce nanoparticles. In applications section, we discuss the use of different nanoparticles produced in agriculture, removal of heavy metals and pollutants from environment, industry and finally medical applications. We will finish our chapter with the topic of healthy and safe synthesis of nanoparticles produced by different wastes and then conclusion.