Synthesis of CF₃CH₂‐Amides/Propiolamides/Acrylamides: The TfOH Catalyzed Reactions of Nitrile Compounds with CF₃CHN₂

Abstract

An efficient and operationally simple protocol to access N‐(2,2,2‐trifluoroethyl)amides/propiolamides and acrylamides via direct conversion of easily accessible nitriles (aryl/alkyl/alkynyl/vinyl) and in situ generated CF3CHN2 as trifluoroethylating reagent has been developed. The protocol offers broad functional group tolerance under mild reaction conditions. Furthermore, the conversion of trifluoroethylated propiolamide into its triazole analog via Ru‐catalyzed [3+2] cycloadditions using BnN3 clearly indicates its versatility in the synthetic applications.