Synthesis of chiral allene moiety from Morita–Baylis–Hillman adduct of isatin derivatives via Claisen rearrangement

Stereoselective Synthesis of Axially Chiral Allenes and Styrenes via Chiral Phosphoric Acid Catalysis: An Overview

“…Allenes (1,2-propadiene derivatives) are an important class of compounds and have gained increasing attention as interesting building blocks in synthetic organic chemistry. They have two cumulative carbon–carbon double bonds, and their characteristic reactivity and unique steric properties originate from propadienyl structures. − They first appeared in the chemical literature over 140 years ago when van’t Hoff predicted their existence in a now historic publication in 1875. , …”

Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry

“…The chemistry of indoline-2,3-dione (isatin) − functionalization at the 1,3,4,5,6-positions leads to attractive applications among major classifications of chemical, biological, and medicinal fields of science. Functionalization of these positions is well established in the literature, such as Morita–Baylis–Hillman addition reaction − (MBH adduct formation at C-3 position), substitution reactions ( N -alkylation, aromatic electrophilic substitution), oxidation, and reduction. To conduct one particular reaction in the core structure of the isatin molecule, some of the positions have to be protected using protection–deprotection chemistry.…”