Synthesis of Chiral Macrocycles Based on Bispidine

Bispidine-Based Macrocycles: Achievements and Perspectives

“…To change the anti-configuration to the syn at the bis-amide fragment, bispidine must undergo a chair-boat conformational transition, which is energetically unfavorable for a small cycle [18]. The same authors reported [19] the chiral analogues of the 16-N4 CO Fe1-macrocycles, using as the starting material both (S) and (R) enantiomers of alanine instead of the glycine used in [17].…”

“…In any case, from the point of view of the selective intermolecular interactions, the most promising examples of bispidine are those containing an amine rather than amide functionality. The same authors reported [19] the chiral analogues of the 16-N 4 CO Fe 1 -macrocycles, using as the starting material both (S) and (R) enantiomers of alanine instead of the glycine used in [17].…”