Synthesis of Chiral <scp>β‐Lactams</scp> by <scp>Pd‐Catalyzed</scp> Enantioselective Amidation of Methylene C(sp<sup>3</sup>)–H Bonds Enabled by a <scp>2‐Pyridylisopropyl</scp> Auxiliary<sup>†</sup>

Nitrogen-containing organic compounds are ubiquitous in natural products, drug molecules and organic intermediates. Therefore, the introduction of nitrogenous functional groups into organic compounds is of great significance. Despite transition metalcatalyzed C-N coupling reaction provided an effcient strategy to access these ntrogen-containing compounds, extra steps are generally required to obtain the pre-functionalized starting materials. Recently, transi-tionmetalcatalyzed C-H amination has emerged as a more atom-and step-economical strategy to construct C-N bonds. Compared to the noble metals (e.g. palladium and rhodium), base metal catalysts, such as copper, cobalt and nickel, have attracted dramatic attentions, due to their earth abundance, cost effectiveness, and unique catalytic activities. Herein, the recent advances in copper-, cobalt-and nickel-catalyzed C-H amination reactions assisted by directing groups were summmarized according to the types of base metals, C-H bonds, and amination reagents with an emphasis on the discussion of various amination reagents and their application. Finally, the limitations and development trend of this research field are analyzed and prospected.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Synthesis of Chiral β‐Lactams by Pd‐Catalyzed Enantioselective Amidation of Methylene C(sp³)–H Bonds Enabled by a 2‐Pyridylisopropyl Auxiliary^†

Cited by 6 publications

References 11 publications

C–H activation: A strategic approach toward lactams using transition metals

C–H activation: A strategic approach toward lactams using transition metals

Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

Recent Advances in Base Metal (Copper, Cobalt and Nickel)-Catalyzed Directed C—H Amination

Contact Info

Product

Resources

About

Synthesis of Chiral β‐Lactams by Pd‐Catalyzed Enantioselective Amidation of Methylene C(sp3)–H Bonds Enabled by a 2‐Pyridylisopropyl Auxiliary†

Cited by 6 publications

References 11 publications

C–H activation: A strategic approach toward lactams using transition metals

C–H activation: A strategic approach toward lactams using transition metals

Coordination-assisted, transition-metal-catalyzed enantioselective desymmetric C–H functionalization

Recent Advances in Base Metal (Copper, Cobalt and Nickel)-Catalyzed Directed C—H Amination

Contact Info

Product

Resources

About

Synthesis of Chiral β‐Lactams by Pd‐Catalyzed Enantioselective Amidation of Methylene C(sp³)–H Bonds Enabled by a 2‐Pyridylisopropyl Auxiliary^†