Synthesis of chitosan-g-poly(acrylamide)/ZnS nanocomposite for controlled drug delivery and antimicrobial activity

Gupta, Divya; Singh, Devender; Kothiyal, N.C.; Saini, Adesh K.; Singh, Virender; Pathania, Deepak

doi:10.1016/j.ijbiomac.2015.01.008

Cited by 50 publications

(17 citation statements)

References 58 publications

(48 reference statements)

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“…The acetic acid had no relevant role on antimicrobial activity, because it was not an experimental variable: all the films, including the control film QS2, contained the same quantity of diluted acetic acid, and we observed that QS2 had weaker antimicrobial activity than the films with extracts (see Table 2). The same behavior was observed in the research of Gupta et al, they concluded that the addition of poly (acrylamide)/ZnS improves the antimicrobial activity of chitosan, not the acetic acid presence [38] and Moreira et al, they indicated that the addition of sodium caseinate enhances the antimicrobial activity of chitosan, not the acetic acid [39]. In both researches, chitosan solutions were prepared using acetic acid solution at 1% in all their samples.…”

Section: Resultssupporting

confidence: 65%

Antimicrobial, Optical and Mechanical Properties of Chitosan–Starch Films with Natural Extracts

Lozano-Navarro

Díaz-Zavala

Velasco‐Santos

et al. 2017

IJMS

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Natural extracts possess several kinds of antioxidants (anthocyanins, betalains, thymol, carvacrol, and resveratrol) that have also demonstrated antimicrobial properties. In order to study these properties, extracts from cranberry, blueberry, beetroot, pomegranate, oregano, pitaya, and resveratrol (from grapes) were obtained. Growth inhibition tests of mesophilic aerobes, coliforms, and fungi were conducted in films prepared from the extracts in accordance with Mexican Official Norms (NOM). Optical properties such as transparency and opacity, mechanical properties, and pH were also analyzed in these materials. The films with beetroot, cranberry, and blueberry extracts demonstrated the best antimicrobial activity against various bacteria and fungi in comparison with unmodified chitosan–starch film. This study shows that the addition of antioxidants improved the antimicrobial performance of these films. It was also found that antimicrobial properties are inherent to the films. These polymers combined with the extracts effectively inhibit or reduce microorganism growth from human and environmental contact; therefore, previous sterilization could be unnecessary in comparison with traditional plastics. The presence of extracts decreased transmittance percentages at 280 and 400 nm, as well as the transparency values, while increasing their opacity values, providing better UV–VIS light barrier properties. Despite diminished glass transition temperatures (Tg), the values obtained are still adequate for food packaging applications.

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Section: Resultssupporting

confidence: 65%

Antimicrobial, Optical and Mechanical Properties of Chitosan–Starch Films with Natural Extracts

Lozano-Navarro

Díaz-Zavala

Velasco‐Santos

et al. 2017

IJMS

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“…It has received a great deal of attention for medical and pharmaceutical applications owing to its excellent biocompatibility, negligible immunogenicity, and low cytotoxicity [22,23,24]. Additionally, numerous studies have reported its antimicrobial activity, which make it an attractive biopolymer for the development of drug delivery systems in treating infectious diseases [25,26,27]. Previously, we have shown that 30 min incubation time with chitosan following PDI can potentiate the bactericidal efficacy in planktonic cells and biofilms [28].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Photodynamic Inactivation against Periodontal Bacteria Mediated by a Chitosan Hydrogel in a 3D Gingival Model

Peng

Hsieh

Chen

et al. 2016

IJMS

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Chitosan hydrogels containing hydroxypropyl methylcellulose (HPMC) and toluidine blue O were prepared and assessed for their mucoadhesive property and antimicrobial efficacy of photodynamic inactivation (PDI). Increased HPMC content in the hydrogels resulted in increased mucoadhesiveness. Furthermore, we developed a simple In Vitro 3D gingival model resembling the oral periodontal pocket to culture the biofilms of Staphylococcus aureus (S. aureus), Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), and Porphyromonas gingivalis (P. gingivalis). The PDI efficacy of chitosan hydrogel was examined against periodontal biofilms cultured in this 3D gingival model. We found that the PDI effectiveness was limited due to leaving some of the innermost bacteria alive at the non-illuminated site. Using this 3D gingival model, we further optimized PDI procedures with various adjustments of light energy and irradiation sites. The PDI efficacy of the chitosan hydrogel against periodontal biofilms can significantly improve via four sides of irradiation. In conclusion, this study not only showed the clinical applicability of this chitosan hydrogel but also the importance of the light irradiation pattern in performing PDI for periodontal disease.

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“…An appropriate amount of FeS was added into the reaction mixture while stirring for about 45 minutes. The resulting mixture was set in a microwave reactor at 333 K for a period of 15-20 minutes at 15 psi pressure [22]. The product was washed copiously with deionized water to take out any homopolymer that is created during the reaction.…”

Section: Fabrication Of Fes/chitosan Graft Poly(acrylamide) Nanocompomentioning

confidence: 99%

“…A band at 1401 cm − 1 was due to C-N vibrational stretch which was an indication of the grafting between chitosan and polyacrylamide [30]. Peaks found below 500 cm − 1 were as a result of Fe-S stretching mode [22,29]. The shift in peak positions of Fe-S bands indicated the interaction of the copolymer with the nanocomposite.…”

Section: Ftir Analysismentioning

confidence: 99%

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FeS Encapsulated Chitosan Graft Polyacrylamide Nanocomposite for the Uptake of Model Anionic Eosin Y from Water: Isotherm, Kinetics and Equilibrium Studies.

Danu¹,

Es²,

Fk³

et al. 2020

Preprint

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A novel bio-nanocomposite, FeS encapsulated chitosan grafted polyacrylamide, was successfully synthesized using a grafting technique that employs microwave irradiation. Employing FTIR, SEM, XRD, TEM and SAED analysis, the synthesized nanocomposites were characterized. Thermodynamic and kinetic studies were accomplished using the batch mode via the eosin yellow adsorption from aqueous solution using the nanocomposite. The adsorption process was tailored to the pseudo-second-order kinetic model and the Freundlich isotherm model. The enthalpy change, ∆H° (-12.243 kJ/mol), was an exothermic process. The Gibbs energy, ∆G° (from -5.492 kJ/mol.K to -5.078 kJ/mol.K for temperatures from 300 K to 318 K respectively) values were indications of a thermodynamically feasible reaction process which was spontaneous within the temperature domain. The change in entropy, ∆S° (-0.023 kJ/mol), showed reduced randomness during the adsorption process. The mean free energy of adsorption was 0.408 kJ/mol, which was an indication of physisorption. These results show the possible use of the graft copolymer as an adsorbent in water treatment.

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Synthesis of chitosan-g-poly(acrylamide)/ZnS nanocomposite for controlled drug delivery and antimicrobial activity

Cited by 50 publications

References 58 publications

Antimicrobial, Optical and Mechanical Properties of Chitosan–Starch Films with Natural Extracts

Antimicrobial, Optical and Mechanical Properties of Chitosan–Starch Films with Natural Extracts

Assessment of Photodynamic Inactivation against Periodontal Bacteria Mediated by a Chitosan Hydrogel in a 3D Gingival Model

FeS Encapsulated Chitosan Graft Polyacrylamide Nanocomposite for the Uptake of Model Anionic Eosin Y from Water: Isotherm, Kinetics and Equilibrium Studies.

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