2024
DOI: 10.1002/jbt.23787
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Synthesis of chitosan polyethylene glycol antibody complex for delivery of Imatinib in lung cancer cell lines

Mehrdad Kamali,
Hanieh Jafari,
Fatemeh Taati
et al.

Abstract: Lung cancer is known as the most common cancer. Although the Ramucirumab antibody is a second‐line treatment for lung cancer, the high interstitial fluid pressure limits the antibody's performance. In this way, Imatinib is a chemotherapeutic drug to reduce the interstitial fluid pressure. Up to now, unfortunately, both Ramucirumab and imatinib have not been reported in one nanosystem for cancer therapy. To fulfill this shortcoming, this paper aims to design a chitosan nanocarrier that loads imatinib and attach… Show more

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