Synthesis of Co(II), Ni(II) and Zn(II) Metal Complexes Derived from a Hydrazone Schiff Base: Electrochemical Behavior and Comprehensive Biological Studies

Abstract

The present study deals with the synthesis of (E)-N'-(2,5dimethoxybenzylidene)-2-hydroxybenzohydrazide, a hydrazone Schiff base ligand (HY) and its metal complexes [Co(HY) 2 , Ni(HY) 2 , Zn(HY) 2 ].2H 2 O. The structure of the synthesized ligand was characterized by physico-chemical analytical and spectral techniques. The electrochemical behavior of HY and its complexes were investigated by cyclic voltammetry. Infrared spectral data suggested that HY acts as a tridentate ligand with ONO as the donor atoms. Molar conductivity data showed that all the complexes were non-electrolytic in nature and octahedral geometry of the complexes was confirmed by UV-visible spectrum. TGA studies of the complexes gave a clear idea about the coordination sphere and the process of degradation.Further, HY and its complexes were screened for their in vitro antioxidant, antibacterial and anticancer activities. Among the synthesized complexes, Ni(II) and Zn(II) metal complexes showed prominent antioxidant activity investigated through their scavenging effect on DPPH radical, anticancer activity against MCF-7 and HeLa cancer cells. The molecular docking into P53 cancer mutant protein (PDB ID: 5AB9) was done for the optimization of the investigated compounds as potential cancer cell inhibitors. The observed data infer that all the complexes show promising antimicrobial activity against all of the tested bacterial and fungal species compared to the parent ligand HY.

New Metal(II) Complexes of 2-Hydroxy-N-(2-Hydroxynaph Thalene-1-yl) Methylene Benzohydrazide: Synthesis and Spectroscopic Studies

“…The above determined on the coordination between the metal ions and the ligand through the phenolic and carbonyl oxygen atoms and the nitrogen of the azomethine group. (30)(31)(32) The stretching frequency of 𝛾 (M-Cl) appears at (280-200 cm -1 ) and was not observed in the infrared spectrum of chloride ions that are coordinated with the metal ions located inside the coordination sphere because they are outside the range of the infrared spectrophotometer used. It was concluded that its coordinate from measured the molar conductivity of the prepared complex solutions, as well as based on magnetic and electronic spectra measurements of the prepared complexes.…”

Bimetallic bis-Aroyldihydrazone-Isatin Complexes of High O=V(IV) and Low Cu(II) Valent Ions as Effective Biological Reagents for Antimicrobial and Anticancer Assays

“…Many M II -hydrazone-based chelated coordination compounds have been employed in various biological assays [ 22 ] and in in vitro studies employing in silico methods [ 23 ]. The influence of the alternative central metal ion of different oxidation states was explored in new hydrazone-based complexes [ 24 ], which have been applied in various important biological metabolisms to address medicinal and pharmaceutical demand, e.g., SOD mimetic reactivity [ 25 , 26 ]. Significantly, metallo-triazine hydrazone pincer chelates have been constructed via the coordination between Cu II and Zn II ions concerning their behavior against the cytokine genes and peptide growth action in rabbits [ 27 ].…”