Synthesis of colloidal silica nanoparticles of a tunable mesopore size and their application to the adsorption of biomolecules

Colloidal and spherical mesoporous silica particles: synthesis and new technologies for delivery applications

“…Mesoporous matrix characteristics vary in a broad range with surface area values from 10 to 1283 m 2 / g [28,29], depending on the reaction conditions; the high amount of variables and the lack of systematic studies make any correlation of the sol-gel process with the final properties of the materials very difficult. Higher pore sizes [15,25,30] are definitely obtained by the use of a pore expander or a cosolvent [26], except for the case of SBA-15, where mesopores of 9 nm are usually expected [24]. The highest pore size value obtained should be carefully understood possibly as mesopore cylinders (3 nm of diameter by 32 nm of length).…”

“…Emphasis is made in the requirements to achieve an ideal carrier, a perfect monodispersed sphere, and therefore, a qualitative evaluation of the shape and size dispersion of the particles is provided. Although many authors claimed to synthesize nanoparticles, only those showing proof of nanosized diameters [13,[15][16][17][18][19][20][21] are labeled as MSN (if no proof of crystal structure is shown by XRD). While some MCM-41 materials are listed [12,[22][23][24], only one was found for SBA-15 particles [24] in the submicron range, although resembling more an hexagonal shape, as it will be discussed later.…”

“…2b shows different shapes and mesopores structures reported lately. In regard to surfactants, almost all reports used CTAB or CTAC in basic conditions, and ammonia or sodium hydroxide as catalysts, although some attempts have been made using lysine [25] or triethylamine [15,26]. Some nonionic surfactants such as Triton X-100 [22] and P123 [24] under acid conditions, and even D-(-) fructose [27] have been tested as SDA, the last one with remarkable sphere shape, but low pore size and a disordered structure.…”

Targeting Cancer with Nano-Bullets: Curcumin, EGCG, Resveratrol and Quercetin on Flying Carpets

“…Silica particles are divided into two types according to their structure. The first type of particles is characterized by numerous nanopores and the second one has a comparatively smaller surface area (Yang et al, 2008;Fuertes et al, 2010).…”

Elucidating the effect of different amino-functionalized spherical mesoporous silica characteristics on ribonucleic acid selectivity and adsorption capacity

“…they required only 10 min to reach equilibrium adsorption) and high capacity (7.3 and 2.3 times, respectively) adsorption of lysozymes compared with the stacking rodlike and large spherical MPS materials. Moreover, Fuertes et al tuned the pore size of MPS from 3 to 9 nm by adding a swelling agent (1,3, and N, N-dimethylhexadecylamine), and they found that its hemoglobin adsorption capacity (2080 mg/g) was greater with this larger pore size [16].…”