Synthesis of comb‐branched polyacrylamide with cationic poly[(2‐dimethylamino)ethyl methacrylate dimethylsulfate] quat

Abstract

Comb‐branched polyelectrolytes with polyacrylamide backbones and poly[(2‐dimethylamino)ethyl methacrylate methylsulfate] (polyDMAEMA‐DMS) side chains were prepared by free‐radical macromonomer polymerization. PolyDMAEMA‐DMS macromonomers bearing terminal styrenic moieties were synthesized by living anionic polymerization with lithium 4‐vinylbenzylamide (LiVBA) and lithium N‐isopropyl‐4‐vinylbenzylamide (LiPVBA) as initiators. In the presence of LiCl, LiPVBA initiated a living polymerization of 2‐(dimethylamino)ethyl methacrylate (DMAEMA) and produced polymers with well‐controlled molecular weights and low polydispersities. LiVBA could not directly initiate DMAEMA polymerization. After being capped with two units of dimethylacrylamide, DMAEMA polymerized with an initiator efficiency of 63%. The quaternization of the poly[(2‐dimethylamino)ethyl methacrylate] macromonomer with dimethyl sulfate yielded the cationic polyDMAEMA‐DMS macromonomer. The polyDMAEMA‐DMS macromonomer had a much higher reactivity than acrylamide in free‐radical polymerization. This might have been due to the formation of polyDMAEMA‐DMS micelles in the polymerization system. The high macromonomer reactivity caused composition drift in a batch process. A semibatch method with a constant polyDMAEMA‐DMS feed rate was used to control the copolymer composition. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 2394–2405, 2002

Dual salt precipitation for the recovery of a recombinant protein from Escherichia coli

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Design and Control of Copolymer Composition Distribution in Living Radical Polymerization Using Semi‐Batch Feeding Policies: A Model Simulation

“…Ray et al15 simulated a nitroxide‐mediated copolymerization process in a semi‐batch reactor with a constant comonomer feeding rate, and found that composition drifting could be relieved to some degree. Zhu et al16 used a constant comonomer feeding rate to prepare uniform comb‐structured copolymers of acrylamide with polydimethylaminoethyl methacrylate macromonomer.…”

Synthesis of a New Macromonomer from 2‐(Dimethylamino)ethyl Methacrylate Bearing 1‐(Isopropenylphenyl)‐1,1‐dimethylmethyl Isocyanate Group

“…. Faquan Zeng et al [25] prepared macromonomers using cationic polymerization of 2-(diethylamino)ethyl methacrylate starting from lithium 4-vinylbenzylamide. .…”