Synthesis of compounds related to muscimol (pantherine, agarin)

Gymnemic acid, the antisaccharine principle of Gymnema sylvestre. Isolation and heterogeneity of gymnemic acid A1

“…Excised zones were chromatographically eluted. Dry column chromatography (dec, see Loev and Goodman, 1970) was performed with silica gel (Bio-Sil A, Bio-Rad Laboratories) which had been dried at 120°o vernight and then equilibrated with 15% water. Sample loads were prepared by plating on silica gel from acetone and then drying the silica under vacuum.…”

Ultraviolet- an .gamma.-ray-Induced reactions of nucleic acid constituents. Reactions of purines with ethers and dioxolane

“…All guanosine photoproducts do not possess the absorption band of the H-8 proton in the nmr, thus indicating that the hydrogen atom at C-8 was substituted. The absorption of the sugar moiety in the photoproduct is very similar to that of the starting nucleotide, except for the anomeric proton.lb The 4 H, -CH2CH2-), 5.95 (s, 3 , N-7 CH3), 6.45 (s, 3 , N-3 CH3), 6.64 (s, 3 H, N-l CH3) A 4.82 (m, 1 H, caffeine CH-O), 5.7 (m, 1 H, -CHCH2OH) 6 (d, 3 H, N-7 CH3; J = 3.6 Hz), 6.28 (m, 2 H, -CH2OH), 6.46 (s, 3…”

Prostaglandins and congeners. 7. Synthesis of simplified prostaglandins. Inhibition of gastric acid secretion by 2-(.omega.-carboxyalkyl)-3-alkylcycloalkanones

“…Anal. (Ci5H2603) C, H. (11). In the manner described for the preparation of 3, treatment of 4.20 g (0.0199 mol) of 2-(4-carbethoxybutyl)cyclopent-2-en-l-one< with lithium methylcopper, prepared from 7.60 g (0.0399 mol) of Cu'I and 33.8 ml of 2.29 (0.0770 mol) methyllithium in ether, gave after purification on 10% silver nitrate-impregnated alumina using 19:1 hexane-ethyl acetate 2.44 g (58%) of a colorless oil.…”