Synthesis of coumarin derivatives containing pyrazole and indenone rings as potent antioxidant and antihyperglycemic agents

Kenchappa, Rajappa S.; Bodke, Yadav D.; Chandrashekar, A.; Sindhe, M. Aruna; Peethambar, S. K.

doi:10.1016/j.arabjc.2014.05.029

Cited by 60 publications

(32 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Actually, all newly synthesized coumarin derivatives expressed considerable radical scavenging or antioxidant activity with IC 50 range (1.49-18.79) µg/ml. Our inding came in agreement with Kenchappa et al they found that the presence of electron-withdrawing functional groups have promising antioxidant activities (Kenchappa et al, 2017).…”

Section: Antioxidant Activitysupporting

confidence: 91%

Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives

Al-awad

raheem

Jaccob

2020

ijrps

View full text Add to dashboard Cite

The current work focuses on new architecture, synthesis of coumarin-oxadiazole hybrid derivative products as both these (coumarin ring and oxadiazole) have a wide variety of biological behavior, Compounds containing the nucleus of coumarin (2H-1-benzopyran-2-one) are an interesting class of hetero cycles which hold an important role in the field of natural ingredients and synthetic organic chemistry. It has been exciting medicinal chemists to study native coumarins or synthetic analogs for their application for decades. And they can be further modified to synthesize more effective and potent drugs. Compounds have been characterized by spectrophotometry of physicochemical properties and their structures verified by infrared spectroscopy (FTIR) and nuclear magnetic resonance (1H-NMR) Such new derivatives of coumarinyl-oxadiazole was qualified to estimate the lethal dose, anticancer, anticoagulant and antioxidant activity. Their pharmacological properties depend on their pattern of substitution, compound S4F proved significant anticoagulant activity in concentration (50, 100, 200 mg/ml) similar for heparin, and monitor the coagulation effect on plasma, while compound S4CO give significant anticancer activity against MCF-7 a breast cancer cell. Specific compounds have strong antioxidants with the effective action of radical scavengers; the S4Cl compound with IC50 1.49 is the most potent antioxidant activity note. Basically, all the formulations tested reported satisfactory behavior. The review shows that varieties of coumarin derivatives have synthesized and shown anti-cancer, antioxidant and anti-coagulant potentials. These derivatives synthesis and its biological assay can be further modified in the future to improve the anti-cancer, anti-oxidant and anticoagulant potentials of the versatile coumarin nucleus.

show abstract

Section: Antioxidant Activitysupporting

confidence: 91%

Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives

Al-awad

raheem

Jaccob

2020

ijrps

View full text Add to dashboard Cite

show abstract

“…The spectral characteristics correspond to the literature data. [43] (10). Hydroquinone (1 mmol) and camphene (1 mmol) were placed in a two-necked flask equipped with a thermometer and a condenser.…”

Section: Synthesis Of Alkylphenolsmentioning

confidence: 99%

“…It has been recognized that hydroxycoumarins are effective metal chelators, free radical scavengers and powerful chain breaking antioxidants. [10] Thus, 4hydroxycoumarins used to treat deep venous thrombosis and some cardiovascular diseases [11] demonstrate the anti-inflammatory properties, which have also been associated with their antioxidant activities. [12] A comparative study of the antioxidant activity of several coumarins against liver toxicity induced by carbon tetrachloride showed that 4-methylumbelliferone was completely inactive, whereas other C-6 and C-7 disubstituted coumarins significantly prevented oxidative stress induced by carbon tetrachloride.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel Coumarins withtert‐Butyl and Terpene Substituents

Попова

Шевченко

Chukicheva

et al. 2019

Chemistry & Biodiversity

View full text Add to dashboard Cite

Coumarins with terpene and tert‐butyl substituents were synthesized via Pechmann condensation reaction. New derivatives were investigated in different model system for the exhibition of antioxidant, radical scavenging and membrane‐protective activities. It has been found that 4‐methylcoumarin derivatives with monoterpene moieties exhibit high antioxidant activities. The most active and promising for further investigations is 5‐hydroxy‐6,8‐diisobornyl‐4‐methylcoumarin, containing two isobornyl substituents on the benzopyran ring.

show abstract

“…3-(4-((Z)-(5,6-Dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)-methyl)-1-p-tolyl-1H-pyrazol-3-yl)-2Hchromen-2-one and 3-(4-((Z)-(5,6-dimethoxy-1-oxo-1H-inden-2(3H)-ylidene)-methyl)-1-(4-methoxy phenyl)-1H-pyrazol-3-yl)-2H-chromen-2-one have shown the greatest activity. Furthermore, fraxidin, by inhibiting the formation of inductible nitric oxide synthase, can down-regulate the blood glucose level [38,40] Anti-inflammatory activity:…”

Section: Biological Properties Of Volatile Phenylpropanoidsmentioning

confidence: 99%

Biological Properties of Some Volatile Phenylpropanoids

Ilijeva

Buchbauer

2016

Natural Product Communications

View full text Add to dashboard Cite

Plants and their extracts are the new field of interest for many scientists and also of some pharmaceutical industries. In order to provide more information for their usage in the prevention and treatment of diseases many clinical trials and researches are being carried out. In this review the biological activities and the mechanism of action of volatile phenylpropanoids (PPs) found in essential oils (EOs) are presented. The aim of this overview is to show that volatile PPs found in EOs can exert many of the biological activities which are generally attributed to EOs. Almost all of the PPs possess antimicrobial, anti-inflammatory and anticancer activities. These are related to the different substitution of the phenylpropane molecule. For each isolated group not only one, but more pharmacological activities can be credited.

show abstract

Synthesis of coumarin derivatives containing pyrazole and indenone rings as potent antioxidant and antihyperglycemic agents

Cited by 60 publications

References 41 publications

Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives

Synthesis and Pharmacological Evaluation of Novel Coumarin Derivatives

Synthesis and Biological Evaluation of Novel Coumarins withtert‐Butyl and Terpene Substituents

Biological Properties of Some Volatile Phenylpropanoids

Contact Info

Product

Resources

About