Synthesis of CuO/graphene nanocomposites for nonenzymatic electrochemical glucose biosensor applications

Hsu, Yu-Wei; Hsu, Ting-Kang; Sun, Chia‐Liang; Nien, Yung-Tang; Pu, Nen-Wen; Ger, Ming-Der

doi:10.1016/j.electacta.2012.03.094

Cited by 234 publications

(100 citation statements)

References 47 publications

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“…In terms of selectivity and sensitivity, enzymatic sensors do generally exhibit better performance than non-enzymatic ones. 1,2,5,6 However, as noted earlier, they suffer from several problems including poor stability, high cost, fragility of the enzyme component, and difficulty of active sensing component preparation. 1,2,[5][6][7] Non-enzymatic approaches, therefore, have gained traction in recent years.…”

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confidence: 99%

“…1,2,5,6 However, as noted earlier, they suffer from several problems including poor stability, high cost, fragility of the enzyme component, and difficulty of active sensing component preparation. 1,2,[5][6][7] Non-enzymatic approaches, therefore, have gained traction in recent years. Thus non-enzymatic amperometric sensors [8][9][10][11][12][13] have been electrosynthesized using MnO 2 , CuO, or cobalt oxide/hydroxide as the active sensor materials.…”

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confidence: 99%

“…[3][4][5][6][7] This inorganic semiconductor has also shown good electrochemical activity and capability of promoting facile electron transfer rates at low overpotentials in alkaline electrolytes.…”

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confidence: 99%

“…2,14 Copper(II) oxide (CuO) which is a p-type semiconductor with a bandgap 1.2 eV has been widely used in many applications including catalyst, gas sensor, battery, and biosensor. [3][4][5][6][7] This inorganic semiconductor has also shown good electrochemical activity and capability of promoting facile electron transfer rates at low overpotentials in alkaline electrolytes. 15 Noble metals such as Pt, Au and Ag have been extensively used to improve sensing performance due to their excellent electrocatalytic activity and biocompatibility.…”

mentioning

confidence: 99%

“…Amperometric sensing [1][2][3][4][5][6][7][8][9][10][11][12][13] is a particularly popular approach to glucose sensing but classical methodology is based on enzymatic monitoring using glucose oxidase which oxidizes the catalytic conversion of glucose to glucolactone. However, a perennial problem with the enzymatic approach is the lack of long term stability and robustness of the sensing device.…”

mentioning

confidence: 99%

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Facile Synthesis of Pt-CuO Nanocomposite Films for Non-Enzymatic Glucose Sensor Application

Myung

Kim

Lee

et al. 2016

J. Electrochem. Soc.

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Nanocomposite films of Pt-CuO were synthesized via galvanostatic electrodeposition combined with galvanic replacement and post-synthesis thermal anneal. First, Cu-Cu 2 O composite was prepared by galvanostatic electrodeposition; heat-treatment of the as-prepared Cu-Cu 2 O composite at 375 • C for 10 h resulted in a CuO electrode showing response to glucose with long term stability. Further enhanced response to glucose was obtained with a Pt-CuO electrode, which was synthesized by galvanic replacement of Cu-Cu 2 O in 10 mM PtCl 4 solution for 30 s followed by annealing at 375 • C for 10 h. The resulting Pt-CuO electrode showed excellent response to glucose in alkaline solution with an analytical sensitivity of 3812 μAmM −1 cm −2 , a limit of detection (LOD) of 7.5 μM, and a linear response range to glucose up to 0.6 mM. These results may be extended to the fabrication of other noble metal-metal oxide nanocomposite electrodes for sensor applications. Millions of people worldwide are afflicted with diabetes, a disease necessitating regular monitoring of blood glucose levels. Amperometric sensing 1-13 is a particularly popular approach to glucose sensing but classical methodology is based on enzymatic monitoring using glucose oxidase which oxidizes the catalytic conversion of glucose to glucolactone. However, a perennial problem with the enzymatic approach is the lack of long term stability and robustness of the sensing device. In terms of selectivity and sensitivity, enzymatic sensors do generally exhibit better performance than non-enzymatic ones. 1,2,5,6 However, as noted earlier, they suffer from several problems including poor stability, high cost, fragility of the enzyme component, and difficulty of active sensing component preparation. 1,2,[5][6][7] Non-enzymatic approaches, therefore, have gained traction in recent years. Thus non-enzymatic amperometric sensors [8][9][10][11][12][13] have been electrosynthesized using MnO 2 , CuO, or cobalt oxide/hydroxide as the active sensor materials. Several reviews are available in the area of non-enzymatic glucose sensors. [8][9][10][11][12][13] Among the non-enzymatic glucose sensing components based on metals and metal oxides, CuO is one of the more promising materials due to its low cost, high stability and earth abundance.2,14 Copper(II) oxide (CuO) which is a p-type semiconductor with a bandgap 1.2 eV has been widely used in many applications including catalyst, gas sensor, battery, and biosensor. [3][4][5][6][7] This inorganic semiconductor has also shown good electrochemical activity and capability of promoting facile electron transfer rates at low overpotentials in alkaline electrolytes. 15Noble metals such as Pt, Au and Ag have been extensively used to improve sensing performance due to their excellent electrocatalytic activity and biocompatibility.2 Especially, Pt-based metal oxides have been proposed for improving the sensitivity and selectivity of non-enzymatic glucose sensors.1,2,4 Unlike CuO-based glucose sensors, however, there is more limited precedent ...

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