Synthesis of cyclopentadienyl ruthenium complexes bearing pendant chelating picolinates through an electrophilic precursor

Abstract

This note reports the facile synthesis of two ruthenium cyclopentadienyl half-sandwich complexes functionalized with coordinating alpha-picolinates. The synthetic approach involves the (eta(5)-chloromethylcyclopentadienyl)(eta(6)-benzene)ruthenium(II) cation as a useful common building block for cyclopentadienyl complexes bearing anchored ligands.

X-ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex

“…In recent years, ruthenium complexes have gained much attention [19][20][21][22][23] in attempts to overcome the downsides of platinum complexes. Organometallic complexes and half-sandwich complexes of Ru(II) emerged as promising scaffolds for anticancer drug design.…”

The key role of coligands in novel ruthenium(II)-cyclopentadienyl bipyridine derivatives: Ranging from non-cytotoxic to highly cytotoxic compounds

“…6 ] synthesis was adapted from[37]. Briefly, benzeneruthenium(II) chloride dimer (1.0 g, 2.0 mmol) was added to a 500 mL round bottomed flask and dissolved in ≈ 300 mL of acetonitrile.…”