Synthesis of Cysteine Modified MoS₂ Nanocomposite: A Biocompatible Electrochemical Sensor Material and its Application to the Determination of Antidiabetic Dapagliflozin

Abstract

Herein, for the first time, a new generation cysteine modified MoS2 (Cys@MoS2) based electrochemical sensor was reported. The electrochemical behaviour of dapagliflozin (DAP) was investigated through differential pulse voltammetry (DPV) on the developed sensor (Cys@MoS2/GCE). The transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), x‐ray diffraction spectroscopy (XRD) and x‐ray photoelectron spectroscopy (XPS) methods were performed for structural and morphological characterizations of Cys@MoS2 nanocomposite. On the surface of Cys@MoS2/GCE, an irreversible anodic peak was observed at 1324 mV. Under the optimal conditions, linear calibration curve with two working ranges between 2.0–60.0 μM and 60.0–110.0 μM were obtained and limit of detection was found to be 1.6 μM. The developed sensor was successfully applied to determine the content of DAP in pharmaceutical sample with satisfying recovery results. It is concluded that Cys@MoS2/GCE is a reliable, easy to apply and cost‐effective sensor for the routine DAP analysis in pharmaceutical samples.

A sulfonated graphene supported nano copper MoS2 network for non-enzymatic simultaneous sensing of dopamine and serotonin

“…MoS 2 is one such TMD that has riveted researchers over the past two decades due to its superior specific surface area, better porosity, and electronic conductivity as it allows shifting from a multi-layered network of indirect bandgap 1.29 eV to a single-layered network of direct bandgap 1.9 eV making it a principal choice amongst scientist for sensitive and rapid sensing applications. [27][28][29][30] However, the lack of sufficient active sites presents a major limitation to the use of pristine MoS 2 . 31,32 Combining it with noble metal nanoparticles (MNPs) becomes a suitable choice to address this issue.…”