Synthesis of d-pilocarpine-N-14CH3

The synthesis of tetralabeled histidine 15 described. Glycine‐15N was converted essentially by literature procedures to 4‐chloromethylimidazole‐3‐15N‐2,5‐2H2. Alkylation of ethyl acetamidocyanoacetate‐2‐13C, followed by acid hydrolysis and decarboxylation yielded DL‐histidine‐α‐ 13C‐3‐15N‐2,5‐2H2. The compound is useful as a mass spectrometric standard for the measurement of histidine and metabolites in biological media.

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Synthesis of multilabeled histidine

Soohoo

Lawson

DeGraw

1977

Labelled Comp Radiopharmac

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Quantitative Analysis of Degradation Products in Pilocarpine Hydrochloride Ophthalmic Formulations

Neville

Hasan

Smith

1977

Journal of Pharmaceutical Sciences

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Measurement of Pilocarpine and Its Degradation Products by High-Performance Liquid Chromatography

O’Donnell

Sandman

Drake

1980

Journal of Pharmaceutical Sciences

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Synthesis of d-pilocarpine-N-14CH3

Cited by 9 publications

References 1 publication

Synthesis of multilabeled histidine

Synthesis of multilabeled histidine

Quantitative Analysis of Degradation Products in Pilocarpine Hydrochloride Ophthalmic Formulations

Measurement of Pilocarpine and Its Degradation Products by High-Performance Liquid Chromatography

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