Synthesis of Dendrimers via Sonogashira Coupling Reaction of Alkyne-focal Fréchet Type Dendrons

Recent mechanistic developments and next generation catalysts for the Sonogashira coupling reaction

“…His research interest includes the synthesis of biologically active compounds analogues of natural products. More details at http://www.luizclaudiobarbosa.com.br natural products, 2,3 pharmaceuticals of biological activity, 4,5 non-linear optical materials and molecular electronics, [6][7][8] dendrimeric and polymeric materials, [9][10][11] macrocycles with acetylene links 12 and polyalkynylated molecules. 13,14 Although the Sonogashira reaction became the most popular route for carrying out alkynylation of aryl or alkenyl halides, the standard Pd catalyzed and Cu co-catalyzed Sonogashira reactions has some major drawbacks including the use of highly expensive Pd catalysts (sometimes required in high loadings), difficulties in recovering these catalysts, high reaction temperatures, air sensitivity of transition-metal complexes and the use of large amounts of ligands and amines.…”