Abstract:Malaria continues to be a serious and debilitating disease. The emergence and spread of high‐level resistance to multiple antimalarial drugs by Plasmodium falciparum has brought about an urgent need for new treatments that will be active against multidrug resistant malaria infections. One such treatment, ELQ‐331 (MMV‐167), an alkoxy carbonate prodrug of 4(1H)‐quinolone ELQ‐300, is currently in preclinical development with the Medicines for Malaria Venture. Clinical development of ELQ‐331 or similar compounds w… Show more
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