Synthesis of deuterium‐labeled simvastatin

Abstract

This study describes the synthesis of deuterium-labeled simvastatin. The stable isotope-labeled compound was prepared starting from lovastatin in nine steps with 9% overall yield.

Determination of isotope abundance for deuterium‐labeled compounds by quantitative 1H NMR + 2H NMR

“…To date, various methods have been developed for the detection of isotope abundance, such as infrared spectroscopy (IR), 12 Raman spectroscopy, 13 mass spectrometry (MS), [14][15][16][17][18][19] and quantitative nuclear magnetic resonance (qNMR). [20][21][22][23] Among these methods, MS and qNMR have emerged as the two classical methods for measuring isotope abundance.…”

Rapid characterization of isotopic purity of deuterium‐labeled organic compounds and monitoring of hydrogen–deuterium exchange reaction using electrospray ionization‐high‐resolution mass spectrometry

“…12 With the rapid development of analytical instruments and increasing requirements under new trends, the use of isotopic purity characterization methods has substantially increased. Currently, the research strategies of isotopic purity of stable isotopes mainly contain a series of methods based on mass spectrometry (MS), [13][14][15][16] infrared spectroscopy (IR), 17,18 Raman spectroscopy, 19 and quantitative nuclear magnetic resonance (qNMR). [20][21][22][23][24] Precise quantification of isotopic purity is imperative for scientific research and the quality control of deuterium-labeled reagents.…”