Synthesis of diastereomeric, deoxy and ring-expanded sulfone analogues of aigialomycin D

Modular Total Syntheses of the Marine-Derived Resorcylic Acid Lactones Cochliomycins A and B Using a Late-Stage Nozaki–Hiyama–Kishi Macrocyclization Reaction

“…The first members of what is now a rather large family of natural products were described more than 50 years ago, and new ones continue to be reported on a regular basis. , The extraordinary range of biological properties displayed by the RALs, which include (among other things) antimalarial, antiviral, antifungal, nematocidal, and antiparasitic activities, has attracted significant attention although probably not as much as the capacities of some of them to act as potent and highly selective inhibitors of kinases and the chaperone heat shock protein 90 (Hsp90). , As such, certain RALs have come to be regarded as important leads for the development of new oncolytic agents. Certainly, an impressive range of derivatization and analoguing programs , has been launched on this basis and such efforts have even led to a number of clinical trials …”

Stereodivergent routes in organic synthesis: marine natural products, lactones, other natural products, heterocycles and unnatural compounds

“…It displays moderate growth inhibitory activity against the human epidermoid carcinoma (KB) and breast cancer (BC-1) cell lines. Harvey and coworkers 9 have synthesized several analogues of this natural product in order to study the growth inhibitory activity against the HL-60 leukaemic cell line. Starting from D-ribose, enantiodivergent routes allow the synthesis of two dienes which were used as chiral building blocks.…”

Stereoselective total synthesis of the antiplasmodial resorcylic acid lactone paecilomycin F

“…Over the years, these molecules have emerged as common targets for total synthesis and have led medicinal chemists to design analog programmes leading to a number of clinical trials. [12][13][14][15] Chen et al have recently isolated six new resorcylic acid lactones, namely paecilomycin A-F [16][17][18] ( Figure 1) along with other known RALs from the mycelial solid culture of Paecilomyces fungus SC0924. Interestingly, when these compounds were subjected to screening for plasmodicidal activity, paecilomycin F was found to display antiplasmodial activity against Plasmodium falciparum line 3D7 with an IC 50 value of 20.0 nM and moderate activity against P. falciparum line Dd2.…”