SYNTHESIS OF DIBENZO[f,l]- 8,10-BISDEHYDRO[17]ANNULENONE

Abstract

An annelated [17]annulenone (3) was prepared starting from o-ethynylcinnamaldehyde (1) in order to examine the effect of annelation on the ring current of the inner seventeen membered ring. It was found that two benzene rings reduce a paramagnetic ring current arising from polarization of a carbonyl group in the inner ring.

Synthesis of New Trifluoromethylated Hydroxyethylamine‐Based Scaffolds

“…[9][10][11][12] On the other hand, trifluoromethyl peptides and peptidomimetics play a crucial role in the development of analogues of protease inhibitors. [13][14][15][16] Due to their specific physico-chemical features (highly hydrophobic, electronrich and sterically demanding), the fluorinated groups can greatly modify the behaviour of a molecule in a biological environment. [17][18][19][20][21] Indeed, the incorporation of trifluoromethyl groups into peptides and peptidomimetics can improve their resistance to metabolism and modify their structural properties and, hence, their binding with an enzyme catalyst or any other additive.…”