Synthesis of Dibenzothiazolyldibenzo‐18‐Crown‐6 and its Applications in Colorimetric Recognition of Palladium and as Antimicrobial Agent

Abstract

Dibenzothiazolyldibenzo‐18‐crown‐6‐ether was designed and synthesized by formylation of dibenzo‐18‐crown‐6‐ether followed by condensation with 2‐aminothiophenol. A simple and rapid UV‐Visible spectrophotometric method is developed for detection of trace of palladium ions. Furthermore it was assessed for antimicrobial activity against bacterial strains Staphylococcus aureus (Gram+ve), Escherichia coli (Gram−ve) as well as fungal strains Aspergillus niger and Candida albicans respectively.

Direct synthetic routes to functionalised crown ethers

“…Formylbenzocrowns represent useful intermediates, since they can be easily converted to a wide range of functional groups. CEs modified according to Wada's procedure have been used for the synthesis of molecular tweezers containing cyclidene-Ni complexes 83 and BODIPY, 84 and derivatised with benzimidazole, 85 benzothiazolyl- 86 and porphyrins. 87 3.2.4.…”

A redox-responsive macrocycle based on the crown ether C7Te for enhanced bacterial inhibition

“…[20][21][22] Functionalized supramolecular nanomaterials based on crown-ether macrocycles have been utilized in controlling bacterial infections, although research on their antimicrobial activity is limited, and their antimicrobial efficacy falls below that of conventional disinfectants. [23][24][25] Using redox-responsive crownether macrocycles as cofactors for traditional disinfectants may help combat microbial resistance from long-term traditional disinfectant use and substantially enhance the antimicrobial efficiency of crown-ether macrocycles. Drug repurposing, a strategy to identify new applications for approved drugs beyond their original indications, not only reduces research investment and risk but also shortens the timeline of drug discovery and development.…”